| Colombia Regional League | 2022/08/15 15:13 | Real Santuario v Medellin City FC | L | 4-0 |
| Colombia Regional League | 2022/08/02 19:17 | Medellin City FC v Universidad de Antioquia | L | 0-1 |
| Colombia Regional League | 2022/07/11 16:00 | CD Gallegol v Medellin City FC | W | 2-4 |
| Colombia Regional League | 2022/07/05 15:23 | Medellin City FC v E.D.P IND. Medellin | W | 4-1 |
| Colombia Regional League | 2022/06/16 12:19 | Molino Viejo v Medellin City FC | L | 3-1 |
| Colombia Regional League | 2022/05/27 15:00 | Club Deportivo La Chalaca v Medellin City FC | L | 4-1 |
| Colombia Regional League | 2022/05/24 15:00 | Medellin City FC v Estudiantes de Medellin | W | 5-2 |
| Colombia Regional League | 2022/05/16 14:19 | Lula FC v Medellin City FC | L | 1-0 |
| Colombia Regional League | 2022/08/16 15:11 | FC Leones Reserves v Lula FC | L | 2-7 |
| Colombia Regional League | 2022/07/26 15:30 | FC Leones Reserves v Club Deportivo La Chalaca | L | 3-4 |
| Colombia Regional League | 2022/07/02 21:16 | Total Soccer FC v FC Leones Reserves | L | 3-2 |
| Colombia Regional League | 2022/05/30 19:29 | Estudiantes de Medellin v FC Leones Reserves | W | 0-2 |
| Colombia Regional League | 2022/05/24 15:00 | FC Leones Reserves v Atletico Nacional Medellin Reserves | W | 2-1 |
| Colombia Regional League | 2022/05/17 13:00 | Envigado FC Reserves v FC Leones Reserves | L | 4-0 |
| Colombia Regional League | 2022/04/23 17:18 | Real Santuario v FC Leones Reserves | D | 2-2 |
| Colombia Regional League | 2022/04/08 15:12 | FC Leones Reserves v Universidad de Antioquia | W | 3-2 |