| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 3 | 0 | 3 | 7 | 0 | 10 |
| 7 | 14 | 21 | 7 | 7 | 35 |
Lineups
| SF 49ers | BUF Bills |
| Lineup | |
|---|---|
| 77 - OL - Dominick Puni | Christian Benford - DB - 47 |
| 41 - SAF - Jalen Graham | Dawson Knox - TE - 88 |
| 53 - Left back - Dee Winters | Ty Johnson - Right back - 26 |
| 69 - DL - Evan Anderson | Taylor Rapp - SAF - 9 |
| 14 - WR - Ricky Pearsall | Reggie Gilliam - TE - 41 |
| 19 - WR - Jacob Cowing | Ryan Van Demark - OL - 74 |
| 68 - OL - Colton McKivitz | Jalen Virgil - WR - 89 |
| 50 - DT - Khalil Davis | Josh Allen - QB - 17 |
| 6 - DB - Malik Mustapha | Ed Oliver - DT - 91 |
| 94 - DE - Yetur Gross-Matos | A.J. Epenesa - DE - 57 |
| 35 - Center back - Nick McCloud | Cam Lewis - Center back - 39 |
| 27 - SAF - Ji'Ayir Brown | Taron Johnson - Center back - 7 |
| 76 - OL - Jaylon Moore | Brandon Codrington - DB - 29 |
| 91 - DT - Sam Okuayinonu | Ja'Marcus Ingram - Center back - 46 |
| 78 - OL - Ben Bartch | Joe Andreessen - Left back - 44 |
| - DB - Renardo Green | Nicholas Morrow - Left back - 32 |
| 4 - K - Jake Moody | Khalil Shakir - WR - 10 |
| 30 - SAF - George Odum | Alec Anderson - OL - 70 |
| 7 - Center back - Charvarius Ward | Ray Davis - Right back - 22 |
| 82 - TE - Eric Saubert | Dorian Williams - Left back - 42 |
| 85 - TE - George Kittle | O'Cyrus Torrence - Guard - 64 |
| 23 - Right back - Christian McCaffrey | James Cook - Right back - 4 |
| 46 - LS - Taybor Pepper | Connor McGovern - OG - 66 |
| 64 - Center - Jake Brendel | Terrel Bernard - Left back - 43 |
| 59 - Left back - De'Vondre Campbell | David Edwards - OL - 76 |
| 99 - DT - Maliek Collins | Tyler Bass - K - 2 |
| 56 - OLB - Leonard Floyd | Von Miller - OLB - 40 |
| 18 - WR - Chris Conley | Quinton Jefferson - DT - 71 |
| 43 - FS - Tashaun Gipson | Gregory Rousseau - DE - 50 |
| 40 - Pivot - Pat O'Donnell | Daquan Jones - DT - 92 |
| 54 - Left back - Fred Warner | Quintin Morris - TE - 85 |
| 33 - Center back - Rock Ya-Sin | Austin Johnson - DT - 98 |
| 74 - OL - Spencer Burford | Damar Hamlin - SAF - 3 |
| 24 - Right back - Jordan Mason | Spencer Brown - OT - 79 |
| 49 - Right back - Isaac Guerendo | Amari Cooper - WR - 18 |
| 9 - TE - Brayden Willis | Jordan Phillips - DE - 97 |
| 13 - QB - Brock Purdy | Cole Bishop - SAF - 24 |
| 51 - DL - Robert Beal Jr. | Sedrick Van Pran-Granger - OL - 62 |
| 88 - TE - Jake Tonges | Reid Ferguson - LS - 69 |
| 90 - DT - Kevin Givens | Casey Toohill - DE - 99 |
| 63 - T - Nick Zakelj | Matt Milano - Left back - 58 |
| 93 - DT - Kalia Davis | Mack Hollins - WR - 13 |
| 22 - DB - Isaac Yiadom | Curtis Samuel - WR - 1 |
| 15 - WR - Jauan Jennings | Rasul Douglas - Center back - 31 |
| 1 - WR - Deebo Samuel | Dion Dawkins - OT - 73 |
| 44 - FB - Kyle Juszczyk | Sam Martin - Pivot - 8 |
| Substitutes | |
Events
- 1st Drive - First Down - No #BUF Bills #Q1#12'#160#15
- 1st Drive - Punt #BUF Bills #Q1#12'#160#15
- 2nd Drive - First Down - Yes #SF 49ers #Q1#7'#460#15
- 2nd Drive - Field Goal Attempt #SF 49ers #Q1#7'#460#15
- 1st Score - Field Goal - #SF 49ers #Q1#7'#460#15
- 2nd Score - Touchdown - Davis #BUF Bills #Q1#-1'#916#15
- 1st Quarter Race to 6 - #BUF Bills #Q1#-1'#916#15
- 3rd Drive - First Down - Yes #BUF Bills #Q1#-1'#916#15
- 3rd Drive - Offensive Touch Down - #BUF Bills #Q1#-1'#916#15
- 1 PAT - #BUF Bills #Q1#-1'#916#15
- Score After 1st Quarter - 3-7
- 4th Drive - First Down - Yes #SF 49ers #Q2#8'#384#15
- 4th Drive - Field Goal Attempt #SF 49ers #Q2#8'#384#15
- 3rd Score - Touchdown - Cook #BUF Bills #Q2#8'#405#15
- 2nd Quarter Race to 6 - #BUF Bills #Q2#8'#405#15
- Race to 10 - #BUF Bills #Q2#8'#405#15
- 5th Drive - First Down - Yes #BUF Bills #Q2#8'#405#15
- 5th Drive - Offensive Touch Down - #BUF Bills #Q2#8'#405#15
- 1 PAT - #BUF Bills #Q2#8'#405#15
- 6th Drive - First Down - Yes #SF 49ers #Q2#3'#698#15
- 6th Drive - Punt #SF 49ers #Q2#3'#698#15
- 4th Score - Touchdown - Hollins #BUF Bills #Q2#0'#859#15
- 2nd Quarter Race to 12 - #BUF Bills #Q2#0'#859#15
- Race to 20 - #BUF Bills #Q2#0'#859#15
- 7th Drive - First Down - Yes #BUF Bills #Q2#0'#859#15
- 7th Drive - Offensive Touch Down - #BUF Bills #Q2#0'#859#15
- 1 PAT - #BUF Bills #Q2#0'#859#15
- 8th Drive - First Down - Yes #SF 49ers #Q2#0'#897#15
- 8th Drive - Field Goal Attempt #SF 49ers #Q2#0'#897#15
- Score After 2nd Quarter - 3-21
- 9th Drive - First Down - Yes #SF 49ers #Q3#11'#203#15
- 9th Drive - Turnover #SF 49ers #Q3#11'#203#15
- 10th Drive - First Down - No #BUF Bills #Q3#10'#281#15
- 10th Drive - Punt #BUF Bills #Q3#10'#281#15
- 11th Drive - First Down - No #SF 49ers #Q3#9'#356#15
- 11th Drive - Punt #SF 49ers #Q3#9'#356#15
- 5th Score - Touchdown - Allen #BUF Bills #Q3#6'#537#15
- 3rd Quarter Race to 6 - #BUF Bills #Q3#6'#537#15
- Race to 25 - #BUF Bills #Q3#6'#537#15
- 12th Drive - First Down - Yes #BUF Bills #Q3#6'#537#15
- 12th Drive - Offensive Touch Down - #BUF Bills #Q3#6'#537#15
- 1 PAT - #BUF Bills #Q3#6'#537#15
- 6th Score - Touchdown - Guerendo #SF 49ers #Q3#3'#719#15
- 13th Drive - First Down - Yes #SF 49ers #Q3#3'#719#15
- 13th Drive - Offensive Touch Down - #SF 49ers #Q3#3'#719#15
- 1 PAT - #SF 49ers #Q3#3'#719#15
- 14th Drive - First Down - No #BUF Bills #Q3#0'#887#15
- 14th Drive - Punt #BUF Bills #Q3#0'#887#15
- Score After 3rd Quarter - 10-28
- 15th Drive - First Down - No #SF 49ers #Q4#14'#12#15
- 15th Drive - Turnover #SF 49ers #Q4#14'#12#15
- 7th Score - Touchdown - Allen #BUF Bills #Q4#12'#158#15
- 4th Quarter Race to 6 - #BUF Bills #Q4#12'#158#15
- Race to 30 - #BUF Bills #Q4#12'#158#15
- 16th Drive - First Down - Yes #BUF Bills #Q4#12'#158#15
- 16th Drive - Offensive Touch Down - #BUF Bills #Q4#12'#158#15
- 1 PAT - #BUF Bills #Q4#12'#158#15
- Race to 35 - #BUF Bills #Q4#12'#158#15
- 17th Drive - First Down - No #SF 49ers #Q4#12'#158#15
- 17th Drive - Turnover #SF 49ers #Q4#12'#158#15
- 17th Drive - First Down - No #BUF Bills #Q4#9'#301#15
- 17th Drive - Field Goal Attempt #BUF Bills #Q4#9'#301#15
- 18th Drive - First Down - No #SF 49ers #Q4#8'#418#15
- 18th Drive - Punt #SF 49ers #Q4#8'#418#15