Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Kim Dameron
| NCAAF FCS | 2018/11/10 19:00 | Austin Peay v Eastern Illinois | W | 21-52 |
| NCAAF | 2018/10/27 17:00 | Eastern Kentucky v Eastern Illinois | L | 31-23 |
| NCAAF | 2018/10/20 19:00 | Eastern Illinois v Tennessee Martin | W | 24-21 |
| NCAAF | 2018/10/13 20:00 | Eastern Illinois v Jacksonville State | L | 22-49 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | L | 48-41 |
| NCAAF | 2018/09/29 23:00 | Eastern Illinois v Tennessee Tech | W | 52-38 |
| NCAAF | 2018/09/22 19:00 | Tennessee State v Eastern Illinois | L | 41-40 |
| NCAAF | 2018/09/15 23:00 | Indiana State v Eastern Illinois | L | 55-41 |
| NCAAF FCS | 2018/11/10 17:00 | SE Missouri St v Murray State | L | 38-40 |
| NCAAF FCS | 2018/11/03 18:00 | Tennessee State v SE Missouri St | W | 21-38 |
| NCAAF | 2018/10/27 19:00 | Tennessee Martin v SE Missouri St | W | 33-56 |
| NCAAF | 2018/10/20 18:00 | SE Missouri St v Jacksonville State | W | 37-14 |
| NCAAF | 2018/10/13 18:00 | Austin Peay v SE Missouri St | W | 27-31 |
| NCAAF | 2018/10/06 23:00 | SE Missouri St v Tennessee Tech | W | 70-38 |
| NCAAF | 2018/09/22 20:00 | SE Missouri St v Eastern Kentucky | L | 14-23 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | W | 48-44 |