[5] Alexander Zverev 7-6,6-3 John Isner [10] 2018-11-16 14:00
Stadium: Centre Court Round: 3 Ground: Hardcourt indoor
Head to Head
| Laver Cup | 2018/09/22 18:00 | Alexander Zverev v John Isner | 3-6,7-6,10-7 |
| ATP Madrid | 2018/05/11 20:00 | John Isner v Alexander Zverev | 4-6,5-7 |
| ATP Miami | 2018/04/01 17:00 | Alexander Zverev v John Isner | 7-6,4-6,4-6 |
| ATP Rome | 2017/05/20 13:00 | Alexander Zverev v John Isner | 6-4,6-7,6-1 |
| ATP Miami | 2017/03/27 20:40 | John Isner v Alexander Zverev | 7-6,6-7,6-7 |
| ATP Shanghai | 2016/10/10 07:10 | Alexander Zverev v John Isner | 6-4,6-2 |
Home History
| ATP World Tour Finals | 2018/11/14 14:00 | Novak Djokovic v Alexander Zverev | 6-4,6-1 |
| ATP World Tour Finals | 2018/11/12 14:10 | Alexander Zverev v Marin Cilic | 7-6,7-6 |
| ATP Paris | 2018/11/02 13:00 | Alexander Zverev v Karen Khachanov | 1-6,2-6 |
| ATP Paris | 2018/11/01 13:25 | Alexander Zverev v Diego Schwartzman | 6-4,6-2 |
| ATP Paris | 2018/10/31 11:45 | Alexander Zverev v Frances Tiafoe | 6-4,6-4 |
| ATP Basel | 2018/10/27 12:30 | Marius Copil v Alexander Zverev | 6-3,6-7,6-4 |
| ATP Basel | 2018/10/26 15:10 | Roberto Bautista-Agut v Alexander Zverev | 5-7,3-6 |
| ATP Basel | 2018/10/25 15:00 | Alexei Popyrin v Alexander Zverev | 4-6,4-6 |
Away History
| ATP World Tour Finals | 2018/11/14 20:00 | Marin Cilic v John Isner | 6-7,6-3,6-4 |
| ATP World Tour Finals | 2018/11/12 20:00 | Novak Djokovic v John Isner | 6-4,6-3 |
| ATP Paris | 2018/11/01 12:00 | Karen Khachanov v John Isner | 6-4,6-7,7-6 |
| ATP Paris | 2018/10/31 10:00 | Mikhail Kukushkin v John Isner | 3-6,7-6,6-7 |
| ATP Vienna | 2018/10/25 17:00 | Gael Monfils v John Isner | 6-4,6-4 |
| ATP Vienna | 2018/10/23 13:30 | Cameron Norrie v John Isner | 7-6,4-6,6-7 |
| ATP Stockholm | 2018/10/20 13:00 | John Isner v Ernests Gulbis | 6-1,3-6,3-6 |
| ATP Stockholm | 2018/10/19 19:10 | John Isner v Tennys Sandgren | 7-6,6-7,7-6 |