[7] Wycombe 1-0 Leyton Orient [21] 2016-12-17 15:00
Weather: Cold Stadium: Adams Park Pitch: Good Round: 21
Referee: Robert Lewis Home Manager: Gareth Ainsworth Away Manager: Andy Edwards
Head to Head
| England League 2 | 2016/01/23 15:00 | Wycombe v Leyton Orient | L | 0-2 |
| England League 2 | 2015/09/19 14:00 | Leyton Orient v Wycombe | D | 1-1 |
Home History
| England League 2 | 2016/12/10 15:00 | Notts County v Wycombe | W | 0-2 |
| England EFL Trophy | 2016/12/07 19:45 | Millwall v Wycombe | W | 1-3 |
| England FA Cup | 2016/12/03 15:00 | Chesterfield v Wycombe | W | 0-5 |
| England League 2 | 2016/11/26 15:00 | Wycombe v Hartlepool | W | 2-0 |
| England League 2 | 2016/11/22 19:45 | Newport County v Wycombe | W | 0-1 |
| England League 2 | 2016/11/19 15:00 | Cambridge Utd v Wycombe | W | 1-2 |
| England League 2 | 2016/11/12 15:00 | Wycombe v Morecambe | W | 2-0 |
| England EFL Trophy | 2016/11/09 19:45 | Wycombe v Coventry | L | 2-4 |
Away History
| England League 2 | 2016/12/10 15:00 | Leyton Orient v Accrington Stanley | W | 1-0 |
| England League 2 | 2016/11/26 15:00 | Doncaster v Leyton Orient | L | 3-1 |
| England League 2 | 2016/11/22 19:45 | Leyton Orient v Exeter | L | 0-1 |
| England League 2 | 2016/11/19 15:00 | Leyton Orient v Blackpool | L | 1-2 |
| England League 2 | 2016/11/12 15:00 | Colchester v Leyton Orient | W | 0-3 |
| England EFL Trophy | 2016/11/08 19:45 | Brighton U23 v Leyton Orient | L | 1-0 |
| England FA Cup | 2016/11/06 14:00 | Sheff Utd v Leyton Orient | L | 6-0 |
| England League 2 | 2016/10/29 14:00 | Leyton Orient v Crewe | L | 0-2 |