Home History
| Club Friendly List | 2016/07/23 12:00 | FC Twente v Al Taawon Buraidah | D | 3-3 |
| Club Friendly List | 2016/07/16 13:00 | FC Twente v PAOK Salonika | L | 0-2 |
| Iceland Pre-Season Cup | 2016/07/06 17:00 | FC Twente v FC Nordsjaelland | L | 0-1 |
| Netherlands Eredivisie | 2016/05/08 12:30 | FC Twente v Vitesse | D | 2-2 |
| Netherlands Eredivisie | 2016/05/01 12:30 | Ajax v FC Twente | L | 4-0 |
| Netherlands Eredivisie | 2016/04/20 18:45 | FC Twente v Excelsior | W | 2-0 |
| Netherlands Eredivisie | 2016/04/15 18:00 | De Graafschap v FC Twente | D | 1-1 |
| Netherlands Eredivisie | 2016/04/10 14:45 | FC Twente v Feyenoord | L | 0-1 |
Away History
| Europe Friendlies | 2016/07/23 17:00 | PEC Zwolle v Southampton | W | 0-4 |
| England Premier League | 2016/05/15 14:00 | Southampton v Crystal Palace | W | 4-1 |
| England Premier League | 2016/05/08 12:30 | Tottenham v Southampton | W | 1-2 |
| England Premier League | 2016/05/01 15:30 | Southampton v Man City | W | 4-2 |
| England Premier League | 2016/04/23 14:00 | Aston Villa v Southampton | W | 2-4 |
| England Premier League | 2016/04/16 14:00 | Everton v Southampton | D | 1-1 |
| England Premier League | 2016/04/09 14:00 | Southampton v Newcastle | W | 3-1 |
| England Premier League | 2016/04/03 12:30 | Leicester v Southampton | L | 1-0 |