Head to Head
| Mexico Liga MX | 2016/10/30 02:00 | Club America v Santos Laguna | W | 3-1 |
| CONCACAF Champions Cup | 2016/04/06 02:00 | Club America v Santos Laguna | W | 1-0 |
| CONCACAF Champions Cup | 2016/03/17 02:00 | Santos Laguna v Club America | D | 0-0 |
| Mexico Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | W | 2-0 |
| Mexico Liga MX | 2015/08/15 02:30 | Santos Laguna v Club America | W | 0-2 |
| Mexico Liga MX | 2015/03/14 23:00 | Club America v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2014/09/27 02:30 | Santos Laguna v Club America | W | 1-4 |
| Mexico Liga MX | 2014/05/04 02:00 | Santos Laguna v Club America | L | 3-1 |
Home History
| Mexico Liga MX | 2017/01/15 22:00 | Toluca v Club America | L | 2-1 |
| Mexico Liga MX | 2016/12/26 00:30 | Tigres UANL v Club America | L | 4-1 |
| Mexico Liga MX | 2016/12/23 03:00 | Club America v Tigres UANL | D | 1-1 |
| FIFA Club World Cup | 2016/12/18 07:00 | Club America v Atletico Nacional Medellin | L | 5-6 |
| FIFA Club World Cup | 2016/12/15 10:30 | Club America v Real Madrid | L | 0-2 |
| FIFA Club World Cup | 2016/12/11 07:00 | Jeonbuk Motors v Club America | W | 1-2 |
| Mexico Liga MX | 2016/12/05 02:00 | Club America v Necaxa | W | 2-0 |
| Mexico Liga MX | 2016/12/02 03:00 | Necaxa v Club America | D | 1-1 |
Away History
| Mexico Liga MX | 2017/01/16 00:00 | Santos Laguna v Veracruz | W | 2-1 |
| Mexico Liga MX | 2017/01/08 01:00 | Tigres UANL v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2016/11/20 18:00 | Toluca v Santos Laguna | W | 1-2 |
| Mexico Liga MX | 2016/11/07 00:00 | Santos Laguna v Jaguares de Chiapas FC | W | 2-0 |
| Mexico Liga MX | 2016/10/30 02:00 | Club America v Santos Laguna | L | 3-1 |
| Mexico Liga MX | 2016/10/23 23:00 | Santos Laguna v Atlas | D | 2-2 |
| Mexico Liga MX | 2016/10/16 00:06 | Pachuca v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2016/10/01 22:00 | Queretaro v Santos Laguna | D | 1-1 |