Home History
| NFL | 2015/11/29 18:00 | KC Chiefs v BUF Bills | L | 30-22 |
| NFL | 2015/11/24 01:30 | NE Patriots v BUF Bills | L | 20-13 |
| NFL | 2015/11/13 01:25 | NY Jets v BUF Bills | W | 17-22 |
| NFL | 2015/11/08 18:00 | BUF Bills v MIA Dolphins | W | 33-17 |
| NFL | 2015/10/25 13:30 | JAX Jaguars v BUF Bills | L | 34-31 |
| NFL | 2015/10/18 17:00 | BUF Bills v CIN Bengals | L | 21-34 |
| NFL | 2015/10/11 17:00 | TEN Titans v BUF Bills | W | 13-14 |
| NFL | 2015/10/04 17:00 | BUF Bills v NY Giants | L | 10-24 |
Away History
| NFL | 2015/11/29 18:00 | HOU Texans v NO Saints | W | 24-6 |
| NFL | 2015/11/22 18:00 | HOU Texans v NY Jets | W | 24-17 |
| NFL | 2015/11/17 01:30 | CIN Bengals v HOU Texans | W | 6-10 |
| NFL | 2015/11/01 18:00 | HOU Texans v TEN Titans | W | 20-6 |
| NFL | 2015/10/25 17:00 | MIA Dolphins v HOU Texans | L | 44-26 |
| NFL | 2015/10/18 17:00 | JAX Jaguars v HOU Texans | W | 20-31 |
| NFL | 2015/10/09 00:25 | HOU Texans v IND Colts | L | 20-27 |
| NFL | 2015/10/04 17:00 | ATL Falcons v HOU Texans | L | 48-21 |