[51] Adrian Mannarino 6-7,4-6 John Isner [9] 2019-02-22 19:30
Stadium: Stadium Round: 27 Ground: Hardcourt outdoor
Head to Head
| Challenger Shanghai | 2015/10/12 07:30 | Adrian Mannarino v John Isner | 1-6,2-6 |
| ATP Madrid | 2015/05/04 11:00 | Adrian Mannarino v John Isner | 6-7,4-6 |
Home History
| ATP Delray Beach | 2019/02/20 18:00 | Adrian Mannarino v Denis Istomin | 6-2,7-6 |
| ATP Delray Beach | 2019/02/19 20:15 | Adrian Mannarino v Brayden Schnur | 6-2,6-2 |
| ATP New York | 2019/02/12 16:00 | Reilly Opelka v Adrian Mannarino | 2-6,7-6,6-4 |
| ATP Sofia | 2019/02/05 10:00 | Yannick Maden v Adrian Mannarino | 6-4,7-6 |
| Challenger Rennes | 2019/01/23 18:55 | Adrian Mannarino v Jurij Rodionov | 4-6,6-4,3-6 |
| Australian Open | 2019/01/14 00:00 | Kevin Anderson v Adrian Mannarino | 6-3,5-7,6-2,6-1 |
| ATP Sydney | 2019/01/06 04:30 | Jordan Thompson v Adrian Mannarino | 6-3,6-3 |
| ATP Doha | 2019/01/01 14:10 | Dusan Lajovic v Adrian Mannarino | 6-3,7-6 |
Away History
| ATP Delray Beach | 2019/02/20 23:00 | Lukas Lacko v John Isner | 4-6,3-6 |
| ATP Delray Beach | 2019/02/19 20:05 | Peter Polansky v John Isner | 3-6,6-7 |
| ATP New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| ATP New York | 2019/02/16 00:00 | John Isner v Jordan Thompson | 6-4,6-1 |
| ATP New York | 2019/02/14 00:30 | John Isner v Bernard Tomic | 7-6,6-4 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |
| ATP Auckland | 2019/01/08 23:00 | John Isner v Taylor Fritz | 6-7,6-7 |
| ATP World Tour Finals | 2018/11/16 14:00 | Alexander Zverev v John Isner | 7-6,6-3 |