Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager: Tom Matukewicz
| NCAAF FCS | 2018/11/17 19:00 | Eastern Illinois v SE Missouri St | W | 32-38 |
| NCAAF | 2017/09/23 23:00 | Eastern Illinois v SE Missouri St | L | 19-16 |
| NCAAF | 2019/11/09 19:00 | Eastern Kentucky v SE Missouri St | W | 31-38 |
| NCAAF | 2019/11/02 19:00 | SE Missouri St v Tennessee State | W | 32-13 |
| NCAAF | 2019/10/26 18:00 | Tennessee Martin v SE Missouri St | W | 10-17 |
| NCAAF | 2019/10/19 20:00 | SE Missouri St v Jacksonville State | W | 24-21 |
| NCAAF | 2019/10/12 19:00 | SE Missouri St v Austin Peay | L | 24-28 |
| NCAAF | 2019/10/05 23:00 | Tennessee Tech v SE Missouri St | W | 37-43 |
| NCAAF | 2019/09/21 18:00 | SE Missouri St v West Virginia State Yellow Jackets | W | 56-10 |
| NCAAF | 2019/09/14 23:30 | SE Missouri St v Missouri | L | 0-50 |
| NCAAF | 2019/11/09 20:00 | Eastern Illinois v Tennessee State | W | 49-38 |
| NCAAF | 2019/10/26 19:00 | Eastern Kentucky v Eastern Illinois | L | 33-6 |
| NCAAF | 2019/10/19 19:00 | Eastern Illinois v Tennessee Martin | L | 18-27 |
| NCAAF | 2019/10/12 17:00 | Jacksonville State v Eastern Illinois | L | 28-20 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | L | 17-24 |
| NCAAF | 2019/09/28 21:00 | Tennessee Tech v Eastern Illinois | L | 40-29 |
| NCAAF | 2019/09/21 17:00 | Eastern Illinois v Indiana State | L | 6-16 |
| NCAAF | 2019/09/14 19:00 | Illinois State v Eastern Illinois | L | 21-3 |