Western Kentucky 21-38 Louisville 2019-09-14 20:00
Stadium: Nissan Stadium Round: 1
Home Manager: Tyson Helton Away Manager: Scott Satterfield
Home History
| NCAAF | 2019/09/07 23:00 | Western Kentucky v Florida Intl | W | 20-14 |
| NCAAF | 2019/08/29 23:30 | Central Arkansas v Western Kentucky | L | 35-28 |
| NCAAF | 2018/11/24 17:00 | Western Kentucky v Louisiana Tech | W | 30-15 |
| NCAAF | 2018/11/18 00:30 | UTEP v Western Kentucky | W | 16-40 |
| NCAAF | 2018/11/10 22:00 | Western Kentucky v Florida Atlantic | L | 15-34 |
| NCAAF | 2018/11/03 00:00 | Western Kentucky v Middle Tennessee St. | L | 10-29 |
| NCAAF | 2018/10/27 23:30 | Florida Intl v Western Kentucky | L | 38-17 |
| NCAAF | 2018/10/20 23:30 | Old Dominion v Western Kentucky | L | 37-34 |
Away History
| NCAAF | 2019/09/07 23:00 | Eastern Kentucky v Louisville | W | 0-42 |
| NCAAF | 2019/09/03 00:00 | Notre Dame v Louisville | L | 35-17 |
| NCAAF | 2018/11/25 00:00 | Kentucky v Louisville | L | 56-10 |
| NCAAF | 2018/11/17 17:20 | NC State v Louisville | L | 52-10 |
| NCAAF | 2018/11/10 00:00 | Louisville v Syracuse | L | 23-54 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | L | 16-77 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | L | 56-35 |
| NCAAF | 2018/10/13 16:30 | Louisville v Boston College | L | 20-38 |