[1] Clemson 45-10 Louisville [2] 2019-10-19 16:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Dabo Swinney
Head to Head
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | W | 16-77 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | W | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | W | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | W | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | W | 23-17 |
Home History
| NCAAF | 2019/10/12 19:30 | Clemson v Florida State | W | 45-14 |
| NCAAF | 2019/09/28 19:30 | Clemson v North Carolina | W | 21-20 |
| NCAAF | 2019/09/21 23:30 | Charlotte v Clemson | W | 10-52 |
| NCAAF | 2019/09/14 23:30 | Clemson v Syracuse | W | 41-6 |
| NCAAF | 2019/09/07 19:30 | Texas A&M v Clemson | W | 10-24 |
| NCAAF | 2019/08/30 00:00 | Georgia Tech v Clemson | W | 14-52 |
| NCAAF | 2019/01/08 01:00 | Clemson v Alabama | W | 44-16 |
| NCAAF | 2018/12/29 21:00 | Notre Dame v Clemson | W | 3-30 |
Away History
| NCAAF | 2019/10/12 23:30 | Louisville v Wake Forest | W | 62-59 |
| NCAAF | 2019/10/05 16:30 | Boston College v Louisville | W | 39-41 |
| NCAAF | 2019/09/21 19:30 | Louisville v Florida State | L | 24-35 |
| NCAAF | 2019/09/14 20:00 | Western Kentucky v Louisville | W | 21-38 |
| NCAAF | 2019/09/07 23:00 | Eastern Kentucky v Louisville | W | 0-42 |
| NCAAF | 2019/09/03 00:00 | Notre Dame v Louisville | L | 35-17 |
| NCAAF | 2018/11/25 00:00 | Kentucky v Louisville | L | 56-10 |
| NCAAF | 2018/11/17 17:20 | NC State v Louisville | L | 52-10 |