[22] Clemson 38-3 South Carolina [120] 2019-11-30 17:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Will Muschamp Away Manager: Dabo Swinney
Head to Head
| NCAAF | 2018/11/25 00:00 | South Carolina v Clemson | W | 35-56 |
| NCAAF | 2017/11/26 00:30 | Clemson v South Carolina | W | 34-10 |
| NCAAF | 2016/11/27 00:30 | South Carolina v Clemson | W | 7-56 |
| NCAAF | 2015/11/28 17:00 | South Carolina v Clemson | W | 32-37 |
| NCAAF | 2014/11/29 17:00 | Clemson v South Carolina | W | 35-17 |
| NCAAF | 2012/11/24 12:00 | Clemson v South Carolina | L | 17-27 |
| NCAAF | 2011/11/26 12:00 | South Carolina v Clemson | L | 34-13 |
| NCAAF | 2010/11/27 12:00 | Clemson v South Carolina | L | 7-29 |
Home History
| NCAAF | 2019/11/16 20:30 | Wake Forest v Clemson | W | 3-52 |
| NCAAF | 2019/11/10 00:30 | Clemson v NC State | W | 55-10 |
| NCAAF | 2019/11/02 20:00 | Wofford v Clemson | W | 14-59 |
| NCAAF | 2019/10/26 23:30 | Clemson v Boston College | W | 59-7 |
| NCAAF | 2019/10/19 16:00 | Clemson v Louisville | W | 45-10 |
| NCAAF | 2019/10/12 19:30 | Clemson v Florida State | W | 45-14 |
| NCAAF | 2019/09/28 19:30 | Clemson v North Carolina | W | 21-20 |
| NCAAF | 2019/09/21 23:30 | Charlotte v Clemson | W | 10-52 |
Away History
| NCAAF | 2019/11/17 00:30 | South Carolina v Texas A&M | L | 6-30 |
| NCAAF | 2019/11/10 00:00 | Appalachian St v South Carolina | L | 20-15 |
| NCAAF | 2019/11/02 23:30 | Vanderbilt v South Carolina | W | 7-24 |
| NCAAF | 2019/10/26 20:00 | South Carolina v Tennessee | L | 21-41 |
| NCAAF | 2019/10/19 16:00 | Florida v South Carolina | L | 38-27 |
| NCAAF | 2019/10/12 16:00 | South Carolina v Georgia | W | 20-17 |
| NCAAF | 2019/10/02 17:20 | South Carolina v Tennessee | D | 0-0 |
| NCAAF | 2019/09/28 23:30 | Kentucky v South Carolina | W | 7-24 |