Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager: Brock Spack
| NCAAF | 2018/09/08 23:30 | Eastern Illinois v Illinois State | W | 10-48 |
| NCAAF | 2017/09/16 19:00 | Eastern Illinois v Illinois State | W | 13-44 |
| NCAAF | 2019/09/07 23:30 | Morehead State v Illinois State | W | 14-42 |
| NCAAF | 2019/08/31 23:00 | Illinois State v Northern Illinois | L | 10-24 |
| NCAAF FCS | 2018/11/17 18:00 | Youngstown State v Illinois State | W | 28-35 |
| NCAAF FCS | 2018/11/10 18:00 | Illinois State v Indiana State | L | 23-28 |
| NCAAF FCS | 2018/11/03 18:00 | Illinois State v Northern Iowa | L | 16-26 |
| NCAAF | 2018/10/27 17:00 | Illinois State v South Dakota State | L | 28-38 |
| NCAAF | 2018/10/20 19:30 | North Dakota State v Illinois State | L | 28-14 |
| NCAAF | 2018/10/13 19:00 | SO Illinois v Illinois State | W | 3-51 |
| NCAAF | 2019/09/07 19:30 | Eastern Illinois v Indiana | L | 0-52 |
| NCAAF | 2019/08/29 23:00 | Eastern Illinois v Tennessee Chattanooga | L | 10-24 |
| NCAAF FCS | 2018/11/17 19:00 | Eastern Illinois v SE Missouri St | L | 32-38 |
| NCAAF FCS | 2018/11/10 19:00 | Austin Peay v Eastern Illinois | W | 21-52 |
| NCAAF | 2018/10/27 17:00 | Eastern Kentucky v Eastern Illinois | L | 31-23 |
| NCAAF | 2018/10/20 19:00 | Eastern Illinois v Tennessee Martin | W | 24-21 |
| NCAAF | 2018/10/13 20:00 | Eastern Illinois v Jacksonville State | L | 22-49 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | L | 48-41 |