[23] Western Michigan 17-51 Michigan State [41] 2019-09-07 23:30
Stadium: Spartan Stadium Round: 1
Home Manager: Mark Dantonio Away Manager: Tim Lester
Head to Head
| NCAAF | 2017/09/09 19:30 | Western Michigan v Michigan State | L | 14-28 |
| NCAAF | 2015/09/04 23:00 | Western Michigan v Michigan State | L | 24-37 |
| NCAAF | 2010/09/04 12:00 | Michigan State v Western Michigan | L | 38-14 |
| NCAAF | 2009/11/07 12:00 | Michigan State v Western Michigan | L | 49-14 |
| NCAAF | 2003/08/30 12:00 | Michigan State v Western Michigan | L | 26-21 |
Home History
| NCAAF | 2019/08/31 23:00 | Monmouth v Western Michigan | W | 13-48 |
| NCAAF | 2018/12/21 21:00 | BYU v Western Michigan | L | 49-18 |
| NCAAF | 2018/11/21 00:00 | Northern Illinois v Western Michigan | W | 21-28 |
| NCAAF | 2018/11/13 23:00 | Western Michigan v Ball State | L | 41-42 |
| NCAAF | 2018/11/01 23:00 | Ohio v Western Michigan | L | 59-14 |
| NCAAF | 2018/10/25 23:00 | Toledo v Western Michigan | L | 51-24 |
| NCAAF | 2018/10/20 19:00 | Western Michigan v Central Michigan | W | 35-10 |
| NCAAF | 2018/10/13 19:00 | Western Michigan v Bowling Green | W | 42-35 |
Away History
| NCAAF | 2019/08/30 23:00 | Tulsa v Michigan State | W | 7-28 |
| NCAAF | 2018/12/31 20:00 | Michigan State v Oregon | L | 6-7 |
| NCAAF | 2018/11/24 21:00 | Rutgers v Michigan State | W | 10-14 |
| NCAAF | 2018/11/17 17:00 | Michigan State v Nebraska | L | 6-9 |
| NCAAF | 2018/11/10 17:00 | Ohio State v Michigan State | L | 26-6 |
| NCAAF | 2018/11/03 16:00 | Michigan State v Maryland | W | 24-3 |
| NCAAF | 2018/10/27 16:00 | Purdue v Michigan State | W | 13-23 |
| NCAAF | 2018/10/20 16:00 | Michigan v Michigan State | L | 21-7 |