Stadium: A.W. Mumford Stadium Round: 1
Home Manager: Dawson Odums Away Manager: Eric Dooley
| NCAAF | 2018/10/13 22:00 | Southern v Prairie View | L | 38-0 |
| NCAAF | 2017/11/04 21:00 | Southern v Prairie View | L | 37-31 |
| NCAAF | 2019/09/28 21:00 | Grambling State v Prairie View | W | 36-42 |
| NCAAF | 2019/09/21 22:00 | Prairie View v Alcorn State | L | 41-45 |
| NCAAF | 2019/09/14 23:00 | Nicholls State v Prairie View | L | 42-35 |
| NCAAF | 2019/09/08 00:00 | Prairie View v Houston | L | 17-37 |
| NCAAF | 2019/08/31 22:30 | Prairie View v Texas Southern Tigers | W | 44-23 |
| NCAAF FCS | 2018/11/24 19:00 | Texas Southern Tigers v Prairie View | W | 14-60 |
| NCAAF FCS | 2018/11/17 19:00 | Alabama State v Prairie View | W | 13-66 |
| NCAAF FCS | 2018/11/03 19:00 | Prairie View v Jackson State | L | 28-34 |
| NCAAF | 2019/09/28 23:00 | Southern v Arkansas Pine Bluff | W | 31-7 |
| NCAAF | 2019/09/21 22:00 | Southern v Florida A&M | L | 21-27 |
| NCAAF | 2019/09/14 23:00 | Southern v Edward Waters Tigers | W | 61-0 |
| NCAAF | 2019/09/07 16:00 | Southern v Memphis | L | 24-55 |
| NCAAF | 2019/08/31 23:00 | Southern v McNeese State | L | 28-34 |
| NCAAF | 2018/12/01 21:30 | Southern v Alcorn State | L | 28-37 |
| NCAAF FCS | 2018/11/24 22:00 | Grambling State v Southern | W | 28-38 |
| NCAAF FCS | 2018/11/10 22:00 | Arkansas Pine Bluff v Southern | W | 24-56 |