[36] Indiana 31-40 Michigan State [48] 2019-09-28 19:30
Stadium: Spartan Stadium Round: 1
Home Manager: Mark Dantonio Away Manager: Tom Allen
Head to Head
| NCAAF | 2018/09/22 23:30 | Michigan State v Indiana | L | 35-21 |
| NCAAF | 2017/10/21 19:30 | Indiana v Michigan State | L | 9-17 |
| NCAAF | 2016/10/02 00:00 | Michigan State v Indiana | W | 21-24 |
| NCAAF | 2015/10/24 19:30 | Michigan State v Indiana | L | 52-26 |
| NCAAF | 2014/10/18 19:30 | Indiana v Michigan State | L | 17-56 |
| NCAAF | 2012/10/06 12:00 | Indiana v Michigan State | L | 27-31 |
| NCAAF | 2011/11/19 12:00 | Michigan State v Indiana | L | 55-3 |
| NCAAF | 2008/09/27 12:00 | Indiana v Michigan State | L | 29-42 |
Home History
| NCAAF | 2019/09/21 16:00 | Connecticut v Indiana | W | 3-38 |
| NCAAF | 2019/09/14 16:00 | Ohio State v Indiana | L | 51-10 |
| NCAAF | 2019/09/07 19:30 | Eastern Illinois v Indiana | W | 0-52 |
| NCAAF | 2019/08/31 16:00 | Ball State v Indiana | W | 24-34 |
| NCAAF | 2018/11/24 17:00 | Purdue v Indiana | L | 28-21 |
| NCAAF | 2018/11/17 21:00 | Indiana v Michigan | L | 20-31 |
| NCAAF | 2018/11/10 17:00 | Maryland v Indiana | W | 32-34 |
| NCAAF | 2018/10/27 00:00 | Indiana v Minnesota | L | 31-38 |
Away History
| NCAAF | 2019/09/21 16:00 | Michigan State v Northwestern | W | 31-10 |
| NCAAF | 2019/09/14 20:00 | Arizona State v Michigan State | L | 10-7 |
| NCAAF | 2019/09/07 23:30 | Western Michigan v Michigan State | W | 17-51 |
| NCAAF | 2019/08/30 23:00 | Tulsa v Michigan State | W | 7-28 |
| NCAAF | 2018/12/31 20:00 | Michigan State v Oregon | L | 6-7 |
| NCAAF | 2018/11/24 21:00 | Rutgers v Michigan State | W | 10-14 |
| NCAAF | 2018/11/17 17:00 | Michigan State v Nebraska | L | 6-9 |
| NCAAF | 2018/11/10 17:00 | Ohio State v Michigan State | L | 26-6 |