Illinois 37-34 Michigan State 2019-11-09 20:30
Stadium: Spartan Stadium Round: 1
Home Manager: Mark Dantonio Away Manager: Lovie Smith
Head to Head
| NCAAF | 2016/11/05 16:00 | Michigan State v Illinois | W | 27-31 |
| NCAAF | 2010/10/16 12:00 | Michigan State v Illinois | L | 26-6 |
| NCAAF | 2009/10/10 12:00 | Illinois v Michigan State | L | 14-24 |
| NCAAF | 2006/09/30 12:00 | Michigan State v Illinois | W | 20-23 |
| NCAAF | 2005/09/24 12:00 | Illinois v Michigan State | L | 14-61 |
| NCAAF | 2004/10/09 12:00 | Michigan State v Illinois | L | 38-25 |
| NCAAF | 2003/10/11 12:00 | Illinois v Michigan State | L | 14-49 |
| NCAAF | 2000/10/28 12:00 | Michigan State v Illinois | L | 14-10 |
Home History
| NCAAF | 2019/11/02 19:30 | Rutgers v Illinois | W | 10-38 |
| NCAAF | 2019/10/26 16:00 | Illinois v Purdue | W | 24-6 |
| NCAAF | 2019/10/19 16:00 | Wisconsin v Illinois | W | 23-24 |
| NCAAF | 2019/10/12 16:00 | Michigan v Illinois | L | 42-25 |
| NCAAF | 2019/10/05 19:30 | Illinois v Minnesota | L | 17-40 |
| NCAAF | 2019/09/22 00:00 | Nebraska v Illinois | L | 42-38 |
| NCAAF | 2019/09/14 16:00 | Eastern Michigan v Illinois | L | 34-31 |
| NCAAF | 2019/09/07 19:30 | Illinois v Connecticut | W | 31-23 |
Away History
| NCAAF | 2019/10/26 19:30 | Penn State v Michigan State | L | 28-7 |
| NCAAF | 2019/10/12 19:30 | Michigan State v Wisconsin | L | 0-38 |
| NCAAF | 2019/10/05 23:30 | Michigan State v Ohio State | L | 10-34 |
| NCAAF | 2019/09/28 19:30 | Indiana v Michigan State | W | 31-40 |
| NCAAF | 2019/09/21 16:00 | Michigan State v Northwestern | W | 31-10 |
| NCAAF | 2019/09/14 20:00 | Arizona State v Michigan State | L | 10-7 |
| NCAAF | 2019/09/07 23:30 | Western Michigan v Michigan State | W | 17-51 |
| NCAAF | 2019/08/30 23:00 | Tulsa v Michigan State | W | 7-28 |