[40] Michigan State 31-10 Northwestern [82] 2019-09-21 16:00
Stadium: Ryan Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Mark Dantonio
Head to Head
| NCAAF | 2018/10/06 16:00 | Northwestern v Michigan State | L | 29-19 |
| NCAAF | 2017/10/28 19:30 | Michigan State v Northwestern | L | 31-39 |
| NCAAF | 2016/10/15 19:30 | Northwestern v Michigan State | L | 54-40 |
| NCAAF | 2012/11/17 12:00 | Michigan State v Northwestern | L | 20-23 |
| NCAAF | 2011/11/26 12:00 | Northwestern v Michigan State | W | 17-31 |
| NCAAF | 2010/10/23 12:00 | Northwestern v Michigan State | W | 27-35 |
| NCAAF | 2009/10/17 12:00 | Michigan State v Northwestern | W | 24-14 |
| NCAAF | 2008/10/11 12:00 | Northwestern v Michigan State | W | 20-37 |
Home History
| NCAAF | 2019/09/14 20:00 | Arizona State v Michigan State | L | 10-7 |
| NCAAF | 2019/09/07 23:30 | Western Michigan v Michigan State | W | 17-51 |
| NCAAF | 2019/08/30 23:00 | Tulsa v Michigan State | W | 7-28 |
| NCAAF | 2018/12/31 20:00 | Michigan State v Oregon | L | 6-7 |
| NCAAF | 2018/11/24 21:00 | Rutgers v Michigan State | W | 10-14 |
| NCAAF | 2018/11/17 17:00 | Michigan State v Nebraska | L | 6-9 |
| NCAAF | 2018/11/10 17:00 | Ohio State v Michigan State | L | 26-6 |
| NCAAF | 2018/11/03 16:00 | Michigan State v Maryland | W | 24-3 |
Away History
| NCAAF | 2019/09/14 19:30 | UNLV v Northwestern | W | 14-30 |
| NCAAF | 2019/08/31 20:00 | Northwestern v Stanford | L | 7-17 |
| NCAAF | 2019/01/01 00:00 | Northwestern v Utah | W | 31-20 |
| NCAAF | 2018/12/02 01:00 | Northwestern v Ohio State | L | 24-45 |
| NCAAF | 2018/11/24 20:30 | Illinois v Northwestern | W | 16-24 |
| NCAAF | 2018/11/17 17:00 | Northwestern v Minnesota | W | 24-14 |
| NCAAF | 2018/11/10 20:30 | Northwestern v Iowa | W | 14-10 |
| NCAAF | 2018/11/03 23:15 | Notre Dame v Northwestern | L | 31-21 |