Head to Head
| NCAAF | 2007/11/17 12:00 | South Florida v Louisville | L | 55-17 |
| NCAAF | 2006/11/18 12:00 | Louisville v South Florida | W | 31-8 |
| NCAAF | 2005/09/24 12:00 | South Florida v Louisville | L | 45-14 |
| NCAAF | 2004/10/22 12:00 | Louisville v South Florida | W | 41-9 |
| NCAAF | 2003/10/04 12:00 | South Florida v Louisville | L | 31-28 |
Home History
| NCAAF | 2008/10/18 12:00 | Louisville v Middle Tennessee St. | W | 42-23 |
| NCAAF | 2008/10/10 12:00 | Memphis v Louisville | W | 28-35 |
| NCAAF | 2008/09/26 12:00 | Louisville v Connecticut | L | 21-26 |
| NCAAF | 2008/09/17 12:00 | Louisville v Kansas State | W | 38-29 |
| NCAAF | 2008/09/06 12:00 | Louisville v Tennessee Tech | W | 51-10 |
| NCAAF | 2008/08/31 12:00 | Louisville v Kentucky | L | 2-27 |
| NCAAF | 2007/11/29 12:00 | Louisville v Rutgers | W | 41-38 |
| NCAAF | 2007/11/17 12:00 | South Florida v Louisville | L | 55-17 |
Away History
| NCAAF | 2008/10/18 12:00 | South Florida v Syracuse | W | 45-13 |
| NCAAF | 2008/10/02 12:00 | South Florida v Pittsburgh | L | 21-26 |
| NCAAF | 2008/09/27 12:00 | NC State v South Florida | W | 10-41 |
| NCAAF | 2008/09/20 12:00 | Florida Intl v South Florida | W | 9-17 |
| NCAAF | 2008/09/12 12:00 | South Florida v Kansas | W | 37-34 |
| NCAAF | 2008/09/06 12:00 | Central Florida v South Florida | W | 24-31 |
| NCAAF | 2008/08/30 12:00 | South Florida v Tennessee Martin | W | 56-7 |
| NCAAF Bowl Games | 2007/12/31 12:00 | Oregon v South Florida | L | 56-21 |