[10] Deportivo Santaní 2-1 Guarani Asuncion [4] 2019-10-31 21:00
Stadium: Estadio Juan Jose Vazquez Round: 16
Referee: Juan Gabriel Benitez Home Manager: Mario Vicente Jara Away Manager: Gustavo Costas
Head to Head
| Paraguay Cup | 2019/10/16 23:00 | Guarani Asuncion v Deportivo Santaní | L | 2-1 |
| Paraguay Division Profesional | 2019/08/11 22:30 | Guarani Asuncion v Deportivo Santaní | L | 2-1 |
| Paraguay Division Profesional | 2019/04/29 23:30 | Guarani Asuncion v Deportivo Santaní | D | 0-0 |
| Paraguay Division Profesional | 2019/02/28 22:15 | Deportivo Santaní v Guarani Asuncion | D | 1-1 |
| Paraguay Division Profesional | 2018/12/01 22:40 | Deportivo Santaní v Guarani Asuncion | D | 2-2 |
| Paraguay Division Profesional | 2018/09/15 22:45 | Guarani Asuncion v Deportivo Santaní | L | 1-0 |
| Paraguay Division Profesional | 2018/05/30 21:00 | Guarani Asuncion v Deportivo Santaní | D | 1-1 |
| Paraguay Division Profesional | 2018/03/24 22:40 | Deportivo Santaní v Guarani Asuncion | W | 2-0 |
Home History
| Paraguay Division Profesional | 2019/10/27 20:45 | Sportivo San Lorenzo v Deportivo Santaní | L | 3-2 |
| Paraguay Division Profesional | 2019/10/21 22:00 | Deportivo Santaní v Deportivo Capiata | L | 1-2 |
| Paraguay Cup | 2019/10/16 23:00 | Guarani Asuncion v Deportivo Santaní | L | 2-1 |
| Paraguay Division Profesional | 2019/10/06 20:00 | Club General Diaz v Deportivo Santaní | W | 0-1 |
| Paraguay Division Profesional | 2019/10/01 00:00 | Cerro Porteno v Deportivo Santaní | L | 4-0 |
| Paraguay Division Profesional | 2019/09/26 22:00 | Sportivo Luqueno v Deportivo Santaní | W | 0-1 |
| Paraguay Division Profesional | 2019/09/21 20:30 | Deportivo Santaní v Libertad Asuncion | W | 1-0 |
| Paraguay Cup | 2019/09/17 20:30 | Deportivo Santaní v River Plate Asuncion | W | 1-0 |
Away History
| Paraguay Division Profesional | 2019/10/26 23:15 | Guarani Asuncion v Cerro Porteno | L | 1-2 |
| Paraguay Division Profesional | 2019/10/20 22:45 | Sportivo Luqueno v Guarani Asuncion | L | 1-0 |
| Paraguay Cup | 2019/10/16 23:00 | Guarani Asuncion v Deportivo Santaní | W | 2-1 |
| Paraguay Division Profesional | 2019/10/05 00:00 | Guarani Asuncion v Libertad Asuncion | D | 1-1 |
| Paraguay Division Profesional | 2019/09/28 22:00 | River Plate Asuncion v Guarani Asuncion | W | 0-1 |
| Paraguay Division Profesional | 2019/09/25 00:00 | Nacional Asuncion v Guarani Asuncion | W | 0-2 |
| Paraguay Division Profesional | 2019/09/21 23:00 | Guarani Asuncion v Olimpia Asuncion | D | 1-1 |
| Paraguay Cup | 2019/09/18 22:45 | Guarani Asuncion v Sol de America Pastoreo | W | 5-0 |