Head to Head
| NCAAF | 2009/11/21 12:00 | South Florida v Louisville | L | 34-22 |
| NCAAF | 2008/10/25 12:00 | Louisville v South Florida | W | 24-20 |
| NCAAF | 2007/11/17 12:00 | South Florida v Louisville | L | 55-17 |
| NCAAF | 2006/11/18 12:00 | Louisville v South Florida | W | 31-8 |
| NCAAF | 2005/09/24 12:00 | South Florida v Louisville | L | 45-14 |
| NCAAF | 2004/10/22 12:00 | Louisville v South Florida | W | 41-9 |
| NCAAF | 2003/10/04 12:00 | South Florida v Louisville | L | 31-28 |
Home History
| NCAAF | 2010/11/06 12:00 | Syracuse v Louisville | W | 20-28 |
| NCAAF | 2010/10/30 12:00 | Pittsburgh v Louisville | L | 20-3 |
| NCAAF | 2010/10/23 12:00 | Louisville v Connecticut | W | 26-0 |
| NCAAF | 2010/10/15 12:00 | Louisville v Cincinnati | L | 27-35 |
| NCAAF | 2010/10/09 12:00 | Louisville v Memphis | W | 56-0 |
| NCAAF | 2010/10/02 12:00 | Arkansas State v Louisville | W | 24-34 |
| NCAAF | 2010/09/18 12:00 | Oregon State v Louisville | L | 35-28 |
| NCAAF | 2010/09/11 12:00 | Louisville v Eastern Kentucky | W | 23-13 |
Away History
| NCAAF | 2010/11/03 12:00 | South Florida v Rutgers | W | 28-27 |
| NCAAF | 2010/10/22 12:00 | Cincinnati v South Florida | W | 30-38 |
| NCAAF | 2010/10/14 12:00 | West Virginia v South Florida | L | 20-6 |
| NCAAF | 2010/10/09 12:00 | South Florida v Syracuse | L | 9-13 |
| NCAAF | 2010/10/02 12:00 | South Florida v Florida Atlantic | W | 31-3 |
| NCAAF | 2010/09/25 12:00 | South Florida v Western Kentucky | W | 24-12 |
| NCAAF | 2010/09/11 12:00 | Florida v South Florida | L | 38-14 |
| NCAAF | 2010/09/04 12:00 | South Florida v Stony Brook | W | 59-14 |