Head to Head
| NCAAF | 2010/11/13 12:00 | Louisville v South Florida | W | 21-24 |
| NCAAF | 2009/11/21 12:00 | South Florida v Louisville | W | 34-22 |
| NCAAF | 2008/10/25 12:00 | Louisville v South Florida | L | 24-20 |
| NCAAF | 2007/11/17 12:00 | South Florida v Louisville | W | 55-17 |
| NCAAF | 2006/11/18 12:00 | Louisville v South Florida | L | 31-8 |
| NCAAF | 2005/09/24 12:00 | South Florida v Louisville | W | 45-14 |
| NCAAF | 2004/10/22 12:00 | Louisville v South Florida | L | 41-9 |
| NCAAF | 2003/10/04 12:00 | South Florida v Louisville | W | 31-28 |
Home History
| NCAAF | 2011/11/19 12:00 | South Florida v Miami Florida | L | 3-6 |
| NCAAF | 2011/11/11 12:00 | Syracuse v South Florida | W | 17-37 |
| NCAAF | 2011/11/05 12:00 | Rutgers v South Florida | L | 20-17 |
| NCAAF | 2011/10/22 12:00 | South Florida v Cincinnati | L | 34-37 |
| NCAAF | 2011/10/15 12:00 | Connecticut v South Florida | L | 16-10 |
| NCAAF | 2011/09/29 12:00 | Pittsburgh v South Florida | L | 44-17 |
| NCAAF | 2011/09/24 12:00 | South Florida v UTEP | W | 52-24 |
| NCAAF | 2011/09/17 12:00 | South Florida v Florida A&M | W | 70-17 |
Away History
| NCAAF | 2011/11/19 12:00 | Connecticut v Louisville | W | 20-34 |
| NCAAF | 2011/11/12 12:00 | Louisville v Pittsburgh | L | 14-21 |
| NCAAF | 2011/11/05 12:00 | West Virginia v Louisville | W | 35-38 |
| NCAAF | 2011/10/29 12:00 | Louisville v Syracuse | W | 27-10 |
| NCAAF | 2011/10/21 12:00 | Louisville v Rutgers | W | 16-14 |
| NCAAF | 2011/10/15 12:00 | Cincinnati v Louisville | L | 25-16 |
| NCAAF | 2011/10/08 12:00 | North Carolina v Louisville | L | 14-7 |
| NCAAF | 2011/10/01 12:00 | Louisville v Marshall | L | 13-17 |