Head to Head
| NCAAF | 2009/10/10 12:00 | Louisville v Southern Mississippi | L | 25-23 |
| NCAAF | 2002/11/14 12:00 | Southern Mississippi v Louisville | L | 17-20 |
| NCAAF | 2001/10/16 12:00 | Louisville v Southern Mississippi | L | 24-14 |
| NCAAF | 2000/11/04 12:00 | Southern Mississippi v Louisville | L | 28-49 |
Home History
| NCAAF | 2012/09/22 12:00 | Western Kentucky v Southern Mississippi | L | 42-17 |
| NCAAF | 2012/09/15 12:00 | Southern Mississippi v East Carolina | L | 14-24 |
| NCAAF | 2012/09/01 12:00 | Nebraska v Southern Mississippi | L | 49-20 |
| NCAAF | 2011/12/03 12:00 | Houston v Southern Mississippi | W | 28-49 |
| NCAAF | 2011/11/26 12:00 | Southern Mississippi v Memphis | W | 44-7 |
| NCAAF | 2011/11/17 12:00 | UAB v Southern Mississippi | L | 34-31 |
| NCAAF | 2011/11/12 12:00 | Southern Mississippi v Central Florida | W | 30-29 |
| NCAAF | 2011/11/05 12:00 | East Carolina v Southern Mississippi | W | 28-48 |
Away History
| NCAAF | 2012/09/22 12:00 | Florida Intl v Louisville | W | 21-28 |
| NCAAF | 2012/09/15 12:00 | Louisville v North Carolina | W | 39-34 |
| NCAAF | 2012/09/08 12:00 | Louisville v Missouri St | W | 35-7 |
| NCAAF | 2012/09/02 12:00 | Louisville v Kentucky | W | 32-14 |
| NCAAF | 2011/11/25 12:00 | South Florida v Louisville | W | 24-34 |
| NCAAF | 2011/11/19 12:00 | Connecticut v Louisville | W | 20-34 |
| NCAAF | 2011/11/12 12:00 | Louisville v Pittsburgh | L | 14-21 |
| NCAAF | 2011/11/05 12:00 | West Virginia v Louisville | W | 35-38 |