Home History
| NCAAF | 2010/10/30 12:00 | Mississippi v Auburn | L | 31-51 |
| NCAAF | 2010/10/23 12:00 | Arkansas v Mississippi | L | 38-24 |
| NCAAF | 2010/10/16 12:00 | Alabama v Mississippi | L | 23-10 |
| NCAAF | 2010/10/02 12:00 | Mississippi v Kentucky | W | 42-35 |
| NCAAF | 2010/09/25 12:00 | Mississippi v Fresno State | W | 55-38 |
| NCAAF | 2010/09/18 12:00 | Mississippi v Vanderbilt | L | 14-28 |
| NCAAF | 2010/09/11 12:00 | Tulane v Mississippi | W | 13-27 |
| NCAAF | 2010/09/04 12:00 | Mississippi v Jacksonville State | L | 48-49 |
Away History
| NCAAF | 2010/10/30 12:00 | Ohio v Lafayette | L | 38-31 |
| NCAAF | 2010/10/23 12:00 | Lafayette v Western Kentucky | L | 21-54 |
| NCAAF | 2010/10/16 12:00 | Troy v Lafayette | L | 31-24 |
| NCAAF | 2010/10/08 12:00 | Lafayette v Oklahoma State | L | 28-54 |
| NCAAF | 2010/10/02 12:00 | North Texas v Lafayette | W | 27-28 |
| NCAAF | 2010/09/25 12:00 | Lafayette v Middle Tennessee St. | L | 14-34 |
| NCAAF | 2010/09/11 12:00 | Lafayette v Arkansas State | W | 31-24 |
| NCAAF | 2010/09/04 12:00 | Georgia v Lafayette | L | 55-7 |