Home History
| NCAAF | 2010/11/27 12:00 | USC v Notre Dame | W | 16-20 |
| NCAAF | 2010/11/20 12:00 | Army v Notre Dame | W | 3-27 |
| NCAAF | 2010/11/13 12:00 | Notre Dame v Utah | W | 28-3 |
| NCAAF | 2010/10/30 12:00 | Notre Dame v Tulsa | L | 27-28 |
| NCAAF | 2010/10/23 12:00 | Navy v Notre Dame | L | 35-17 |
| NCAAF | 2010/10/16 12:00 | Notre Dame v Western Michigan | W | 44-20 |
| NCAAF | 2010/10/09 12:00 | Notre Dame v Pittsburgh | W | 23-17 |
| NCAAF | 2010/10/02 12:00 | Boston College v Notre Dame | W | 13-31 |
Away History
| NCAAF | 2010/12/04 12:00 | South Florida v Connecticut | L | 16-19 |
| NCAAF | 2010/11/27 12:00 | Miami Florida v South Florida | W | 20-23 |
| NCAAF | 2010/11/20 12:00 | South Florida v Pittsburgh | L | 10-17 |
| NCAAF | 2010/11/13 12:00 | Louisville v South Florida | W | 21-24 |
| NCAAF | 2010/11/03 12:00 | South Florida v Rutgers | W | 28-27 |
| NCAAF | 2010/10/22 12:00 | Cincinnati v South Florida | W | 30-38 |
| NCAAF | 2010/10/14 12:00 | West Virginia v South Florida | L | 20-6 |
| NCAAF | 2010/10/09 12:00 | South Florida v Syracuse | L | 9-13 |