Home History
| NCAAF | 2010/11/26 12:00 | East Carolina v SMU | L | 38-45 |
| NCAAF | 2010/11/20 12:00 | Rice v East Carolina | L | 62-38 |
| NCAAF | 2010/11/11 12:00 | UAB v East Carolina | W | 42-54 |
| NCAAF | 2010/11/06 12:00 | East Carolina v Navy | L | 35-76 |
| NCAAF | 2010/10/30 12:00 | Central Florida v East Carolina | L | 49-35 |
| NCAAF | 2010/10/23 12:00 | East Carolina v Marshall | W | 37-10 |
| NCAAF | 2010/10/16 12:00 | East Carolina v NC State | W | 33-27 |
| NCAAF | 2010/10/09 12:00 | Southern Mississippi v East Carolina | W | 43-44 |
Away History
| NCAAF | 2010/12/04 12:00 | Auburn v South Carolina | L | 56-17 |
| NCAAF | 2010/11/27 12:00 | Clemson v South Carolina | W | 7-29 |
| NCAAF | 2010/11/20 12:00 | South Carolina v Troy | W | 69-24 |
| NCAAF | 2010/11/13 12:00 | Florida v South Carolina | W | 14-36 |
| NCAAF | 2010/11/06 12:00 | South Carolina v Arkansas | L | 20-41 |
| NCAAF | 2010/10/30 12:00 | South Carolina v Tennessee | W | 38-24 |
| NCAAF | 2010/10/23 12:00 | Vanderbilt v South Carolina | W | 7-21 |
| NCAAF | 2010/10/16 12:00 | Kentucky v South Carolina | L | 31-28 |