Home History
| NCAAF | 2000/10/14 12:00 | Louisville v Cincinnati | W | 38-24 |
| NCAAF | 2000/10/07 12:00 | UAB v Louisville | W | 17-38 |
| NCAAF | 2000/09/30 12:00 | Louisville v Connecticut | W | 41-22 |
| NCAAF | 2000/09/23 12:00 | Florida State v Louisville | L | 31-0 |
| NCAAF | 2000/09/09 12:00 | Louisville v Grambling State | W | 52-0 |
| NCAAF | 2000/09/02 12:00 | Louisville v Kentucky | W | 40-34 |
Away History
| NCAAF | 2000/10/14 12:00 | East Carolina v Army | W | 42-21 |
| NCAAF | 2000/10/07 12:00 | Memphis v East Carolina | L | 17-10 |
| NCAAF | 2000/09/23 12:00 | East Carolina v Syracuse | W | 34-17 |
| NCAAF | 2000/09/16 12:00 | East Carolina v Tulane | W | 37-17 |
| NCAAF | 2000/09/07 12:00 | East Carolina v Virginia Tech | L | 28-45 |
| NCAAF | 2000/09/02 12:00 | Duke v East Carolina | W | 0-38 |