Home History
| NCAAF | 2000/11/18 12:00 | Clemson v South Carolina | W | 16-14 |
| NCAAF | 2000/11/04 12:00 | Florida State v Clemson | L | 54-7 |
| NCAAF | 2000/10/28 12:00 | Clemson v Georgia Tech | L | 28-31 |
| NCAAF | 2000/10/21 12:00 | North Carolina v Clemson | W | 24-38 |
| NCAAF | 2000/10/14 12:00 | Clemson v Maryland | W | 35-14 |
| NCAAF | 2000/10/07 12:00 | Clemson v NC State | W | 34-27 |
| NCAAF | 2000/09/30 12:00 | Duke v Clemson | W | 22-52 |
| NCAAF | 2000/09/23 12:00 | Virginia v Clemson | W | 10-31 |
Away History
| NCAAF | 2000/11/25 12:00 | Virginia Tech v Virginia | W | 42-21 |
| NCAAF | 2000/11/11 12:00 | Central Florida v Virginia Tech | W | 21-44 |
| NCAAF | 2000/11/04 12:00 | Miami Florida v Virginia Tech | L | 41-21 |
| NCAAF | 2000/10/28 12:00 | Virginia Tech v Pittsburgh | W | 37-34 |
| NCAAF | 2000/10/21 12:00 | Syracuse v Virginia Tech | W | 14-22 |
| NCAAF | 2000/10/12 12:00 | Virginia Tech v West Virginia | W | 48-20 |
| NCAAF | 2000/10/07 12:00 | Virginia Tech v Temple | W | 35-13 |
| NCAAF | 2000/09/30 12:00 | Boston College v Virginia Tech | W | 34-48 |