Stadium: Callaway Stadium Round: 1
| NCAAF | 2018/11/10 19:00 | Huntingdon Hawks v Lagrange Panthers | L | 42-14 |
| NCAAF | 2018/11/03 17:00 | Lagrange Panthers v Methodist Monarchs | W | 48-38 |
| NCAAF | 2018/10/27 18:00 | Brevard Tornados v Lagrange Panthers | L | 38-34 |
| NCAAF | 2018/10/20 18:00 | Lagrange Panthers v Maryville Scots | L | 17-37 |
| NCAAF | 2018/10/06 17:00 | Lagrange Panthers v Averett Cougars | L | 14-38 |
| NCAAF | 2018/09/29 17:00 | North Carolina Wesleyan Battling Bishops v Lagrange Panthers | L | 35-14 |
| NCAAF | 2018/09/22 17:00 | Lagrange Panthers v The Apprentice School Builders | W | 42-13 |
| NCAAF | 2018/09/08 22:00 | Lagrange Panthers v Berry Vikings | L | 21-34 |
| NCAAF | 2018/11/10 19:00 | Birmingham Southern Panthers v Centre Colonels | L | 20-56 |
| NCAAF | 2018/11/03 18:00 | Millsaps Majors v Birmingham Southern Panthers | W | 17-34 |
| NCAAF | 2018/10/27 19:00 | Berry Vikings v Birmingham Southern Panthers | L | 26-10 |
| NCAAF | 2018/10/20 19:00 | Birmingham Southern Panthers v Austin Kangaroos | W | 47-35 |
| NCAAF | 2018/10/13 23:00 | Sewanee Tigers v Birmingham Southern Panthers | W | 10-13 |
| NCAAF | 2018/10/06 18:00 | Birmingham Southern Panthers v Hendrix Warriors | W | 57-41 |
| NCAAF | 2018/09/30 00:00 | Trinity Tigers v Birmingham Southern Panthers | L | 24-17 |
| NCAAF | 2018/09/22 18:00 | Birmingham Southern Panthers v Rhodes Lynx | L | 10-29 |