Stadium: Ram Stadium Round: 1
| NCAAF | 2018/11/10 17:00 | Shepherd Rams v Virginia Wise Highland Cavaliers | L | 16-21 |
| NCAAF | 2018/11/03 16:00 | University of Charleston Golden Eagles v Shepherd Rams | W | 20-25 |
| NCAAF | 2018/10/27 16:00 | Shepherd Rams v W. Virginia Bobcats | W | 58-35 |
| NCAAF | 2018/10/20 17:00 | Urbana Blue Knights v Shepherd Rams | W | 21-44 |
| NCAAF | 2018/10/13 16:00 | Shepherd Rams v Fairmont State | L | 17-38 |
| NCAAF | 2018/10/06 16:00 | West Liberty Hilltoppers v Shepherd Rams | W | 14-26 |
| NCAAF | 2018/09/29 16:00 | Shepherd Rams v Concord University Mountain Lions | W | 61-21 |
| NCAAF | 2018/09/22 16:00 | West Virginia State Yellow Jackets v Shepherd Rams | W | 7-27 |
| NCAAF | 2018/11/10 17:00 | Lake Erie v Ohio Dominican Panthers | W | 6-62 |
| NCAAF | 2018/11/03 16:00 | Ohio Dominican Panthers v Kentucky Wesleyan | W | 65-7 |
| NCAAF | 2018/10/27 17:05 | East Stroudsburg Warriors v Ohio Dominican Panthers | W | 35-48 |
| NCAAF | 2018/10/20 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 24-23 |
| NCAAF | 2018/10/13 17:00 | Ohio Dominican Panthers v Malone University Pioneers | W | 57-17 |
| NCAAF | 2018/10/06 23:00 | Walsh U. Cavaliers v Ohio Dominican Panthers | W | 10-20 |
| NCAAF | 2018/09/29 16:00 | Ohio Dominican Panthers v Alderson Broaddus Battlers | W | 66-27 |
| NCAAF | 2018/09/22 23:05 | Findlay Oilers v Ohio Dominican Panthers | W | 21-34 |