Stadium: Spratt Memorial Stadium Round: 1
| NCAAF | 2019/10/05 18:00 | Washburn Ichabods Football v Missouri Western Griffons | W | 21-46 |
| NCAAF | 2019/09/28 19:00 | Northeastern State Riverhawks v Missouri Western Griffons | W | 23-58 |
| NCAAF | 2019/09/22 00:00 | Missouri Western Griffons v Central Missouri Mules | L | 45-48 |
| NCAAF | 2019/09/13 00:00 | Fort Hays State University Tigers v Missouri Western Griffons | W | 17-28 |
| NCAAF | 2019/09/06 00:00 | Missouri Western Griffons v NW Missouri State | L | 35-45 |
| NCAAF | 2018/11/10 19:00 | Missouri Western Griffons v Lindenwood | L | 23-27 |
| NCAAF | 2018/11/03 16:00 | Nebraska Kearney v Missouri Western Griffons | W | 17-25 |
| NCAAF | 2018/10/27 18:00 | Missouri Western Griffons v Pittsburgh State Gorillas | L | 14-34 |
| NCAAF | 2019/10/05 19:00 | Missouri Southern Lions v Central Missouri Mules | L | 42-71 |
| NCAAF | 2019/09/29 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | L | 44-3 |
| NCAAF | 2019/09/21 23:00 | Missouri Southern Lions v NW Missouri State | L | 34-66 |
| NCAAF | 2019/09/12 23:00 | Blue Tigers v Missouri Southern Lions | W | 14-38 |
| NCAAF | 2019/09/05 23:00 | Missouri Southern Lions v Nebraska Kearney | L | 27-39 |
| NCAAF | 2018/11/10 20:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 0-41 |
| NCAAF | 2018/11/03 19:00 | Emporia State v Missouri Southern Lions | L | 48-0 |
| NCAAF | 2018/10/27 19:00 | Missouri Southern Lions v Central Oklahoma | L | 0-31 |