Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2019/09/29 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | L | 44-3 |
| NCAAF | 2019/09/21 23:00 | Missouri Southern Lions v NW Missouri State | L | 34-66 |
| NCAAF | 2019/09/12 23:00 | Blue Tigers v Missouri Southern Lions | W | 14-38 |
| NCAAF | 2019/09/05 23:00 | Missouri Southern Lions v Nebraska Kearney | L | 27-39 |
| NCAAF | 2018/11/10 20:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 0-41 |
| NCAAF | 2018/11/03 19:00 | Emporia State v Missouri Southern Lions | L | 48-0 |
| NCAAF | 2018/10/27 19:00 | Missouri Southern Lions v Central Oklahoma | L | 0-31 |
| NCAAF | 2018/10/20 22:00 | Missouri Southern Lions v Northeastern State Riverhawks | W | 24-19 |
| NCAAF | 2019/09/28 18:00 | Central Missouri Mules v Washburn Ichabods Football | W | 55-27 |
| NCAAF | 2019/09/22 00:00 | Missouri Western Griffons v Central Missouri Mules | W | 45-48 |
| NCAAF | 2019/09/13 00:00 | Northeastern State Riverhawks v Central Missouri Mules | W | 7-70 |
| NCAAF | 2019/09/06 00:00 | Central Missouri Mules v Fort Hays State University Tigers | W | 34-30 |
| NCAAF | 2018/11/10 19:00 | Central Missouri Mules v NW Missouri State | L | 21-48 |
| NCAAF | 2018/11/03 18:00 | Lindenwood v Central Missouri Mules | W | 28-31 |
| NCAAF | 2018/10/27 18:30 | Central Missouri Mules v Nebraska Kearney | W | 42-35 |
| NCAAF | 2018/10/20 19:05 | Pittsburgh State Gorillas v Central Missouri Mules | L | 48-28 |