Stadium: Deeds Field at Piper Stadium Round: 1
| NCAAF | 2019/10/26 17:00 | Wittenberg Tigers v Denison Big Red | W | 13-24 |
| NCAAF | 2019/10/19 18:00 | Wooster Scots v Denison Big Red | W | 21-38 |
| NCAAF | 2019/10/12 19:00 | Denison Big Red v Oberlin Yeomen | W | 49-0 |
| NCAAF | 2019/10/05 22:00 | Allegheny Gators v Denison Big Red | W | 7-42 |
| NCAAF | 2019/09/28 18:00 | Wabash Little Giants v Denison Big Red | L | 34-20 |
| NCAAF | 2019/09/21 23:00 | Denison Big Red v Hiram Terriers | W | 66-7 |
| NCAAF | 2019/09/07 23:00 | Denison Big Red v Ohio Northern Polar Bears | W | 42-13 |
| NCAAF | 2018/11/17 17:00 | Mount Union v Denison Big Red | L | 60-0 |
| NCAAF | 2019/10/26 17:00 | Depauw Tigers v Allegheny Gators | W | 8-6 |
| NCAAF | 2019/10/19 18:00 | Ohio Wesleyan Battling Bishops v Depauw Tigers | L | 28-13 |
| NCAAF | 2019/10/12 17:00 | Hiram Terriers v Depauw Tigers | W | 7-21 |
| NCAAF | 2019/10/05 17:00 | Depauw Tigers v Wooster Scots | W | 31-26 |
| NCAAF | 2019/09/28 17:00 | Depauw Tigers v Wittenberg Tigers | L | 10-17 |
| NCAAF | 2019/09/21 16:00 | Kenyon Lords v Depauw Tigers | W | 7-21 |
| NCAAF | 2019/09/14 18:00 | Central Dutch v Depauw Tigers | L | 45-19 |
| NCAAF | 2018/11/10 18:07 | Wabash Little Giants v Depauw Tigers | L | 24-17 |