Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2019/09/19 23:00 | Manchester Spartans v Defiance Yellow Jackets | L | 52-21 |
| NCAAF | 2018/09/15 22:00 | Manchester Spartans v Defiance Yellow Jackets | L | 57-26 |
| NCAAF | 2019/11/02 17:30 | Rose Hulman Engineers v Defiance Yellow Jackets | L | 53-6 |
| NCAAF | 2019/10/26 17:30 | Franklin College Grizzlies v Defiance Yellow Jackets | L | 28-0 |
| NCAAF | 2019/10/12 17:30 | Defiance Yellow Jackets v Hanover | L | 0-42 |
| NCAAF | 2019/10/05 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 59-6 |
| NCAAF | 2019/09/28 17:30 | Anderson Ravens v Defiance Yellow Jackets | L | 56-29 |
| NCAAF | 2019/09/19 23:00 | Manchester Spartans v Defiance Yellow Jackets | L | 52-21 |
| NCAAF | 2019/09/14 18:30 | Hope Flying Dutchmen v Defiance Yellow Jackets | L | 80-6 |
| NCAAF | 2019/09/07 22:00 | Albion Britons v Defiance Yellow Jackets | L | 56-6 |
| NCAAF | 2019/11/02 17:30 | Manchester Spartans v Bluffton Beavers | L | 14-26 |
| NCAAF | 2019/10/26 17:30 | Hanover v Manchester Spartans | L | 56-7 |
| NCAAF | 2019/10/19 17:30 | Franklin College Grizzlies v Manchester Spartans | W | 21-30 |
| NCAAF | 2019/10/12 17:30 | Manchester Spartans v Mount St. Joseph Lions | L | 14-47 |
| NCAAF | 2019/09/28 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 35-52 |
| NCAAF | 2019/09/19 23:00 | Manchester Spartans v Defiance Yellow Jackets | W | 52-21 |
| NCAAF | 2019/09/14 22:00 | Manchester Spartans v Alma College Scots | L | 7-35 |
| NCAAF | 2019/09/05 23:30 | Manchester Spartans v Trine Thunder | L | 21-38 |