Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2019/11/02 18:00 | Central Oklahoma v Missouri Southern Lions | L | 52-27 |
| NCAAF | 2019/10/26 19:00 | Northeastern State Riverhawks v Missouri Southern Lions | W | 7-86 |
| NCAAF | 2019/10/19 21:00 | Missouri Southern Lions v Washburn Ichabods Football | L | 19-49 |
| NCAAF | 2019/10/12 21:00 | Missouri Western Griffons v Missouri Southern Lions | L | 43-34 |
| NCAAF | 2019/10/05 19:00 | Missouri Southern Lions v Central Missouri Mules | L | 42-71 |
| NCAAF | 2019/09/29 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | L | 44-3 |
| NCAAF | 2019/09/21 23:00 | Missouri Southern Lions v NW Missouri State | L | 34-66 |
| NCAAF | 2019/09/12 23:00 | Blue Tigers v Missouri Southern Lions | W | 14-38 |
| NCAAF | 2019/11/02 19:00 | Emporia State v Washburn Ichabods Football | L | 17-37 |
| NCAAF | 2019/10/26 18:00 | Missouri Western Griffons v Emporia State | L | 28-0 |
| NCAAF | 2019/10/19 19:00 | Emporia State v Central Missouri Mules | L | 27-34 |
| NCAAF | 2019/10/13 00:00 | Fort Hays State University Tigers v Emporia State | L | 19-3 |
| NCAAF | 2019/10/05 19:00 | Emporia State v NW Missouri State | L | 23-34 |
| NCAAF | 2019/09/28 23:00 | Blue Tigers v Emporia State | W | 7-50 |
| NCAAF | 2019/09/21 19:00 | Emporia State v Nebraska Kearney | L | 21-31 |
| NCAAF | 2019/09/15 00:00 | Pittsburgh State Gorillas v Emporia State | L | 47-23 |