Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2019/10/26 22:00 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-13 |
| NCAAF | 2019/10/19 17:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 19-21 |
| NCAAF | 2019/10/12 20:00 | Newberry Wolves v Virginia Wise Highland Cavaliers | L | 30-7 |
| NCAAF | 2019/10/05 18:00 | Lenoir Rhyne Bears v Virginia Wise Highland Cavaliers | L | 63-6 |
| NCAAF | 2019/09/28 17:00 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | L | 42-7 |
| NCAAF | 2019/09/21 16:00 | Virginia Wise Highland Cavaliers v Mars Hill Lions | L | 14-21 |
| NCAAF | 2019/09/14 23:00 | Tennessee Tech v Virginia Wise Highland Cavaliers | L | 31-14 |
| NCAAF | 2019/09/07 16:00 | Virginia Wise Highland Cavaliers v Chowan Hawks | W | 40-22 |
| NCAAF | 2019/10/26 20:00 | Limestone Saints v Lenoir Rhyne Bears | L | 20-28 |
| NCAAF | 2019/10/19 17:30 | Mars Hill Lions v Limestone Saints | L | 35-28 |
| NCAAF | 2019/10/12 22:00 | Wingate Bulldogs v Limestone Saints | L | 34-3 |
| NCAAF | 2019/10/05 17:00 | Limestone Saints v Catawba College | W | 52-24 |
| NCAAF | 2019/09/28 23:00 | Unc Pembroke Braves v Limestone Saints | W | 25-41 |
| NCAAF | 2019/09/21 17:00 | Limestone Saints v Tusculum Pioneers | L | 10-38 |
| NCAAF | 2019/09/14 23:00 | Limestone Saints v West Georgia | L | 14-24 |
| NCAAF | 2019/09/07 22:00 | West Alabama Tigers v Limestone Saints | L | 35-18 |