[35] Jan-Lennard Struff 6-4,5-7,11-13 John Isner [19] 2019-12-14 13:00
Stadium: Center Court
Head to Head
| US Open | 2019/08/29 18:30 | John Isner v Jan-Lennard Struff | 6-3,7-6,7-6 |
| ATP Paris | 2016/11/03 15:20 | Jan-Lennard Struff v John Isner | 4-6,7-6,3-6 |
| ATP Vienna | 2016/10/24 14:30 | Jan-Lennard Struff v John Isner | 7-6,3-6,4-6 |
| US Open | 2014/08/28 16:40 | Jan-Lennard Struff v John Isner | 6-7,4-6,2-6 |
Home History
| Diriyah Tennis Cup Consolation Draw | 2019/12/13 11:45 | Jan-Lennard Struff v Michael Mmoh | 6-4,6-1 |
| Diriyah Tennis Cup | 2019/12/12 17:00 | Daniil Medvedev v Jan-Lennard Struff | 6-3,6-1 |
| Davis Cup | 2019/11/22 18:15 | Daniel Evans v Jan-Lennard Struff | 7-6,3-6,7-6 |
| Davis Cup | 2019/11/21 11:35 | Jan-Lennard Struff v Cristian Garin | 7-6,6-7,6-7 |
| Davis Cup | 2019/11/20 12:20 | Diego Schwartzman v Jan-Lennard Struff | 3-6,6-7 |
| ATP Paris | 2019/10/31 16:00 | Jan-Lennard Struff v Jo-Wilfried Tsonga | 6-2,4-6,6-7 |
| ATP Paris | 2019/10/29 12:05 | Karen Khachanov v Jan-Lennard Struff | 6-7,6-3,5-7 |
| ATP Paris | 2019/10/28 11:15 | Jan-Lennard Struff v Yoshihito Nishioka | 4-6,7-5,6-2 |
Away History
| Diriyah Tennis Cup Consolation Draw | 2019/12/13 10:00 | John Isner v Stan Wawrinka | 7-6,7-5 |
| Diriyah Tennis Cup | 2019/12/12 13:00 | Fabio Fognini v John Isner | 7-6,6-4 |
| ATP Paris | 2019/10/30 12:15 | Cristian Garin v John Isner | 7-6,7-6 |
| ATP Shanghai | 2019/10/10 07:00 | Novak Djokovic v John Isner | 7-5,6-3 |
| ATP Shanghai | 2019/10/09 04:30 | Lucas Pouille v John Isner | 5-7,3-6 |
| ATP Shanghai | 2019/10/08 04:30 | Alex De Minaur v John Isner | 6-7,4-6 |
| ATP Beijing | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| ATP Beijing | 2019/10/03 06:30 | John Isner v Daniel Evans | 7-6,7-5 |