Head to Head
| England U23 Premier League Cup | 2019/10/05 14:00 | Southampton U23 v Stoke U23 | D | 1-1 |
| England Premier League 2 | 2019/01/04 19:00 | Southampton U23 v Stoke U23 | L | 2-0 |
| England Premier League 2 | 2018/08/20 18:00 | Stoke U23 v Southampton U23 | L | 1-4 |
| England Premier League 2 | 2018/01/29 19:00 | Stoke U23 v Southampton U23 | L | 0-2 |
| England Premier League 2 | 2017/09/18 18:00 | Southampton U23 v Stoke U23 | L | 3-0 |
Home History
| England U23 Premier League Cup | 2020/02/21 12:02 | Nottm Forest U23 v Stoke U23 | D | 0-0 |
| England Premier League 2 | 2020/02/17 19:00 | West Ham U23 v Stoke U23 | D | 2-2 |
| England Premier League 2 | 2020/02/03 19:00 | Stoke U23 v Reading U23 | W | 3-0 |
| England Premier League 2 | 2020/01/10 19:00 | Fulham U23 v Stoke U23 | W | 0-2 |
| England Premier League 2 | 2020/01/06 19:00 | Stoke U23 v Swansea U23 | L | 0-1 |
| England Premier League 2 | 2019/12/16 19:00 | Stoke U23 v Middlesbrough U23 | L | 2-3 |
| England Premier League 2 | 2019/12/09 19:00 | Sunderland U23 v Stoke U23 | W | 0-1 |
| England U23 Premier League Cup | 2019/12/02 19:00 | Stoke U23 v Nottm Forest U23 | W | 4-0 |
Away History
| England U23 Premier League Cup | 2020/02/21 19:01 | Bournemouth U23 v Southampton U23 | L | 3-2 |
| England Premier League 2 | 2020/02/14 19:00 | Blackburn U23 v Southampton U23 | D | 2-2 |
| England U23 Premier League Cup | 2020/02/07 18:58 | Nottm Forest U23 v Southampton U23 | L | 2-1 |
| England Premier League 2 | 2020/02/03 19:00 | Southampton U23 v Wolverhampton U23 | W | 1-0 |
| England Premier League 2 | 2020/01/13 19:00 | Liverpool U23 v Southampton U23 | L | 5-0 |
| England Premier League 2 | 2020/01/06 19:00 | Southampton U23 v Everton U23 | D | 1-1 |
| England Premier League 2 | 2019/12/16 19:00 | Derby U23 v Southampton U23 | L | 4-2 |
| England Premier League 2 | 2019/12/06 19:00 | Southampton U23 v Man City U23 | W | 2-0 |