[3] PIT Penguins 3-1 BUF Sabres [23] 2017-03-21 23:00
Stadium: KeyBank Center Round: 1
Head to Head
| NHL | 2017/03/05 22:00 | BUF Sabres v PIT Penguins | W | 3-4 |
| NHL | 2016/11/20 00:00 | PIT Penguins v BUF Sabres | L | 1-2 |
Home History
| NHL | 2017/03/19 17:00 | FLA Panthers v PIT Penguins | W | 0-4 |
| NHL | 2017/03/17 23:00 | NJ Devils v PIT Penguins | W | 4-6 |
| NHL | 2017/03/15 23:30 | PIT Penguins v PHI Flyers | L | 0-4 |
| NHL | 2017/03/14 01:00 | PIT Penguins v CAL Flames | L | 3-4 |
| NHL | 2017/03/12 03:00 | PIT Penguins v VAN Canucks | W | 3-0 |
| NHL | 2017/03/11 02:00 | PIT Penguins v EDM Oilers | W | 3-2 |
| NHL | 2017/03/09 01:00 | PIT Penguins v WIN Jets | W | 7-4 |
| NHL | 2017/03/05 22:00 | BUF Sabres v PIT Penguins | W | 3-4 |
Away History
| NHL | 2017/03/20 23:30 | BUF Sabres v DET Red Wings | W | 2-1 |
| NHL | 2017/03/18 04:33 | BUF Sabres v ANA Ducks | D | 2-2 |
| NHL | 2017/03/18 02:00 | ANA Ducks v BUF Sabres | W | 1-2 |
| NHL | 2017/03/17 02:30 | BUF Sabres v LA Kings | L | 0-2 |
| NHL | 2017/03/15 02:30 | BUF Sabres v SJ Sharks | L | 1-4 |
| NHL | 2017/03/12 00:00 | CLB Blue Jackets v BUF Sabres | W | 3-5 |
| NHL | 2017/03/11 00:00 | BUF Sabres v CLB Blue Jackets | L | 3-4 |
| NHL | 2017/03/08 00:30 | PHI Flyers v BUF Sabres | L | 6-3 |