Head to Head
| ATP Atlanta | 2019/07/24 23:00 | John Isner v Reilly Opelka | 6-7,7-6,6-7 |
| ATP New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |
Home History
| All American Team Cup | 2020/07/03 22:00 | John Isner v Taylor Fritz | 6-3,6-4 |
| ATP Acapulco | 2020/02/29 00:05 | Taylor Fritz v John Isner | 2-6,7-5,6-3 |
| ATP Acapulco | 2020/02/27 23:00 | John Isner v Tommy Paul | 7-6,3-6,6-2 |
| ATP Acapulco | 2020/02/26 23:40 | John Isner v Marcos Giron | 6-3,7-6 |
| ATP Acapulco | 2020/02/26 03:00 | John Isner v Mischa Zverev | 6-3,7-6 |
| ATP New York | 2020/02/14 00:30 | John Isner v Jordan Thompson | 6-7,7-6,3-6 |
| Australian Open | 2020/01/23 06:35 | John Isner v Alejandro Tabilo | 6-4,6-3,6-3 |
| Australian Open | 2020/01/21 10:00 | John Isner v Thiago Monteiro | 6-7,7-6,7-6,7-6 |
Away History
| All American Team Cup | 2020/07/03 23:30 | Steve Johnson v Reilly Opelka | 6-4,4-6,10-5 |
| Altec Styslinger Tennis Exhibition | 2020/07/01 16:00 | Brandon Nakashima v Reilly Opelka | 4-3,3-3 |
| Altec Styslinger Tennis Exhibition | 2020/06/30 19:00 | Sam Querrey v Reilly Opelka | 4-2,2-4,4-3 |
| Matchplay 120 | 2020/06/25 14:00 | JC Aragone v Reilly Opelka | 1-6,2-6 |
| UTR Pro Match Series | 2020/05/09 20:20 | Reilly Opelka v Miomir Kecmanovic | 4-3,2-4,4-2 |
| UTR Pro Match Series | 2020/05/09 16:00 | Hubert Hurkacz v Reilly Opelka | 4-2,1-4,4-2 |
| UTR Pro Match Series | 2020/05/08 18:15 | Reilly Opelka v Tommy Paul | 3-4,4-1,4-0 |
| UTR Pro Match Series | 2020/05/08 17:00 | Miomir Kecmanovic v Reilly Opelka | 3-4,0-4 |