Head to Head
| ATP Cincinnati | 2017/08/17 21:45 | John Isner v Frances Tiafoe | 7-6,7-5 |
| US Open | 2016/08/29 17:30 | John Isner v Frances Tiafoe | 3-6,4-6,7-6,6-2,7-6 |
Home History
| All American Team Cup | 2020/07/04 22:00 | John Isner v Kevin King | 6-1,6-3 |
| All American Team Cup | 2020/07/03 22:00 | John Isner v Taylor Fritz | 6-3,6-4 |
| ATP Acapulco | 2020/02/29 00:05 | Taylor Fritz v John Isner | 2-6,7-5,6-3 |
| ATP Acapulco | 2020/02/27 23:00 | John Isner v Tommy Paul | 7-6,3-6,6-2 |
| ATP Acapulco | 2020/02/26 23:40 | John Isner v Marcos Giron | 6-3,7-6 |
| ATP Acapulco | 2020/02/26 03:00 | John Isner v Mischa Zverev | 6-3,7-6 |
| ATP New York | 2020/02/14 00:30 | John Isner v Jordan Thompson | 6-7,7-6,3-6 |
| Australian Open | 2020/01/23 06:35 | John Isner v Alejandro Tabilo | 6-4,6-3,6-3 |
Away History
| All American Team Cup | 2020/07/03 16:00 | Sam Querrey v Frances Tiafoe | 4-6,6-7 |
| Challenger Indian Wells | 2020/03/05 19:55 | Frances Tiafoe v Gregoire Barrere | 6-4,2-6,6-7 |
| Challenger Indian Wells | 2020/03/03 19:50 | Frances Tiafoe v Michael Mmoh | 6-4,6-3 |
| ATP Acapulco | 2020/02/25 03:05 | Stan Wawrinka v Frances Tiafoe | 6-3,6-7,7-6 |
| ATP Delray Beach | 2020/02/21 18:10 | Frances Tiafoe v Ugo Humbert | 1-6,2-6 |
| ATP Delray Beach | 2020/02/20 19:35 | Tommy Paul v Frances Tiafoe | 5-7,6-7 |
| ATP Delray Beach | 2020/02/18 01:10 | Emilio Gomez v Frances Tiafoe | 6-7,2-6 |
| Challenger Dallas | 2020/02/08 01:00 | Frances Tiafoe v Denis Kudla | 4-6,6-7 |