[3] Lokomotiv Moscow 2-0 Spartak Moscow [2] 2021-04-11 16:00
Stadium: RZD Arena Round: 25
Referee: Kirill Levnikov Home Manager: Marko Nikolic Away Manager: Domenico Tedesco
Head to Head
| Russia Premier League | 2020/08/23 16:00 | Spartak Moscow v Lokomotiv Moscow | L | 2-1 |
| Russia Premier League | 2020/07/08 17:30 | Spartak Moscow v Lokomotiv Moscow | D | 1-1 |
| Europe Friendlies | 2020/02/05 15:00 | Spartak Moscow v Lokomotiv Moscow | W | 3-5 |
| Russia Premier League | 2019/10/27 13:30 | Lokomotiv Moscow v Spartak Moscow | L | 0-3 |
| Europe Friendlies | 2019/01/29 17:00 | Spartak Moscow v Lokomotiv Moscow | L | 4-0 |
| Russia Premier League | 2018/12/02 16:00 | Spartak Moscow v Lokomotiv Moscow | L | 2-1 |
| Russia Premier League | 2018/08/04 16:00 | Lokomotiv Moscow v Spartak Moscow | D | 0-0 |
| Russia Premier League | 2018/03/04 13:30 | Lokomotiv Moscow v Spartak Moscow | D | 0-0 |
Home History
| Russia Cup | 2021/04/07 16:00 | PFC Sochi v Lokomotiv Moscow | W | 1-3 |
| Russia Premier League | 2021/04/03 11:00 | Rotor Volgograd v Lokomotiv Moscow | W | 0-2 |
| Russia Premier League | 2021/03/18 14:00 | FC Ufa v Lokomotiv Moscow | W | 0-1 |
| Russia Premier League | 2021/03/14 16:00 | Lokomotiv Moscow v PFC Sochi | W | 3-1 |
| Russia Premier League | 2021/03/08 11:00 | Arsenal Tula v Lokomotiv Moscow | W | 0-3 |
| Russia Premier League | 2021/02/27 16:00 | Lokomotiv Moscow v CSKA Moscow | W | 2-0 |
| Russia Cup | 2021/02/21 14:00 | Lokomotiv Moscow v FK Tambov | W | 3-0 |
| Europe Friendlies | 2021/02/14 14:34 | Lokomotiv Moscow v Rostov | W | 2-1 |
Away History
| Russia Premier League | 2021/04/04 16:00 | Rostov v Spartak Moscow | W | 2-3 |
| Russia Premier League | 2021/03/18 16:00 | Spartak Moscow v Ural | W | 5-1 |
| Russia Premier League | 2021/03/13 16:00 | Dinamo Moscow v Spartak Moscow | W | 1-2 |
| Russia Premier League | 2021/03/07 16:00 | Spartak Moscow v Krasnodar | W | 6-1 |
| Russia Premier League | 2021/02/28 11:00 | Spartak Moscow v Rubin Kazan | L | 0-2 |
| Russia Cup | 2021/02/20 16:30 | Dinamo Moscow v Spartak Moscow | L | 2-0 |
| Europe Friendlies | 2021/02/07 12:00 | Spartak Moscow v Riga FC | W | 4-0 |
| Europe Friendlies | 2021/02/06 12:00 | Spartak Moscow v Shakhter Soligorsk | W | 2-1 |