[9] Southampton 0-0 West Ham [10] 2020-12-29 18:00
Stadium: St. Mary's Stadium Round: 16
Referee: Andrew Madley Home Manager: Ralph Hasenhuttl Away Manager: David Moyes
Head to Head
| England Premier League | 2020/02/29 15:00 | West Ham v Southampton | L | 3-1 |
| England Premier League | 2019/12/14 17:30 | Southampton v West Ham | L | 0-1 |
| England Premier League | 2019/05/04 14:00 | West Ham v Southampton | L | 3-0 |
| England Premier League | 2018/12/27 19:45 | Southampton v West Ham | L | 1-2 |
| England Premier League | 2018/03/31 14:00 | West Ham v Southampton | L | 3-0 |
| England Premier League | 2017/08/19 14:00 | Southampton v West Ham | W | 3-2 |
| England Premier League | 2017/02/04 15:00 | Southampton v West Ham | L | 1-3 |
| England Premier League | 2016/09/25 15:00 | West Ham v Southampton | W | 0-3 |
Home History
| England Premier League | 2020/12/26 15:00 | Fulham v Southampton | D | 0-0 |
| England Premier League | 2020/12/19 15:00 | Southampton v Man City | L | 0-1 |
| England Premier League | 2020/12/16 18:00 | Arsenal v Southampton | D | 1-1 |
| England Premier League | 2020/12/13 12:00 | Southampton v Sheff Utd | W | 3-0 |
| England Premier League | 2020/12/07 20:00 | Brighton v Southampton | W | 1-2 |
| England Premier League | 2020/11/29 14:00 | Southampton v Man Utd | L | 2-3 |
| England Premier League | 2020/11/23 20:00 | Wolverhampton v Southampton | D | 1-1 |
| England Premier League | 2020/11/06 20:00 | Southampton v Newcastle | W | 2-0 |
Away History
| England Premier League | 2020/12/27 14:15 | West Ham v Brighton | D | 2-2 |
| England Premier League | 2020/12/21 20:00 | Chelsea v West Ham | L | 3-0 |
| England Premier League | 2020/12/16 20:00 | West Ham v Crystal Palace | D | 1-1 |
| England Premier League | 2020/12/11 20:00 | Leeds v West Ham | W | 1-2 |
| England Premier League | 2020/12/05 17:30 | West Ham v Man Utd | L | 1-3 |
| England Premier League | 2020/11/30 20:00 | West Ham v Aston Villa | W | 2-1 |
| England Premier League | 2020/11/22 14:00 | Sheff Utd v West Ham | W | 0-1 |
| England Premier League | 2020/11/07 20:00 | West Ham v Fulham | W | 1-0 |