[30] Louisville 20-23 Pittsburgh [2] 2020-09-26 16:00
Stadium: Heinz Field Round: 1
Head to Head
| NCAAF | 2015/11/21 20:45 | Pittsburgh v Louisville | L | 45-34 |
| NCAAF | 2012/10/13 12:00 | Pittsburgh v Louisville | W | 35-45 |
| NCAAF | 2011/11/12 12:00 | Louisville v Pittsburgh | L | 14-21 |
| NCAAF | 2010/10/30 12:00 | Pittsburgh v Louisville | L | 20-3 |
| NCAAF | 2008/11/08 12:00 | Pittsburgh v Louisville | L | 41-7 |
| NCAAF | 2007/10/27 12:00 | Louisville v Pittsburgh | W | 24-17 |
| NCAAF | 2006/11/25 12:00 | Pittsburgh v Louisville | W | 24-48 |
| NCAAF | 2005/11/03 12:00 | Louisville v Pittsburgh | W | 42-20 |
Home History
| NCAAF | 2020/09/19 23:30 | Miami Florida v Louisville | L | 47-34 |
| NCAAF | 2020/09/13 00:00 | Western Kentucky v Louisville | W | 21-35 |
| NCAAF | 2019/12/30 21:00 | Mississippi State v Louisville | W | 28-38 |
| NCAAF | 2019/11/30 17:00 | Louisville v Kentucky | L | 13-45 |
| NCAAF | 2019/11/23 21:00 | Syracuse v Louisville | W | 34-56 |
| NCAAF | 2019/11/17 00:30 | Louisville v NC State | W | 34-20 |
| NCAAF | 2019/11/09 20:30 | Louisville v Miami Florida | L | 27-52 |
| NCAAF | 2019/10/26 19:30 | Virginia v Louisville | W | 21-28 |
Away History
| NCAAF | 2020/09/19 16:00 | Syracuse v Pittsburgh | W | 10-21 |
| NCAAF | 2020/09/12 20:00 | Austin Peay v Pittsburgh | W | 0-55 |
| NCAAF | 2019/12/27 01:00 | Pittsburgh v Eastern Michigan | W | 34-30 |
| NCAAF | 2019/11/30 20:30 | Boston College v Pittsburgh | L | 26-19 |
| NCAAF | 2019/11/23 20:30 | Pittsburgh v Virginia Tech | L | 0-28 |
| NCAAF | 2019/11/15 01:00 | North Carolina v Pittsburgh | W | 27-34 |
| NCAAF | 2019/11/02 20:00 | Pittsburgh v Georgia Tech | W | 20-10 |
| NCAAF | 2019/10/26 16:00 | Miami Florida v Pittsburgh | L | 16-12 |