Head to Head
| England National League North | 2019/08/10 14:00 | Southport v Guiseley | L | 3-0 |
| England National League North | 2019/03/02 15:00 | Guiseley v Southport | L | 0-1 |
| England National League North | 2019/01/08 19:45 | Southport v Guiseley | L | 1-0 |
| England National League | 2017/04/01 14:00 | Southport v Guiseley | W | 0-1 |
| England National League | 2016/10/08 14:00 | Guiseley v Southport | W | 2-1 |
| England National League | 2016/03/26 15:00 | Southport v Guiseley | L | 2-0 |
| England National League | 2015/09/22 18:45 | Guiseley v Southport | D | 1-1 |
Home History
| England National League North | 2020/12/08 19:45 | Chorley v Guiseley | L | 1-0 |
| England National League North | 2020/12/05 15:00 | Guiseley v Brackley | L | 1-3 |
| England National League North | 2020/12/01 19:45 | Spennymoor Town v Guiseley | W | 0-2 |
| England National League North | 2020/11/28 15:00 | AFC Telford v Guiseley | L | 2-0 |
| England National League North | 2020/11/24 19:45 | Kettering v Guiseley | D | 1-1 |
| England National League North | 2020/11/21 15:00 | Guiseley v Gloucester | L | 1-2 |
| England National League North | 2020/11/17 19:45 | Guiseley v Darlington 1883 | L | 1-4 |
| England National League North | 2020/10/27 19:45 | Boston Utd v Guiseley | D | 1-1 |
Away History
| England National League North | 2020/12/05 15:00 | Southport v Alfreton Town | D | 1-1 |
| England National League North | 2020/12/02 19:45 | Southport v Farsley Celtic | L | 0-1 |
| England National League North | 2020/11/21 15:00 | Gateshead v Southport | L | 4-1 |
| England National League North | 2020/11/17 19:45 | Bradford P A v Southport | W | 0-2 |
| England National League North | 2020/11/14 15:00 | Southport v Spennymoor Town | L | 0-2 |
| England National League North | 2020/11/10 19:45 | Southport v York | L | 2-3 |
| England National League North | 2020/11/07 15:00 | AFC Telford v Southport | D | 1-1 |
| England National League North | 2020/11/03 20:00 | Kettering v Southport | W | 0-1 |