Head to Head
| England Premier League 2 | 2020/10/03 13:00 | Tottenham U23 v Southampton U23 | L | 2-1 |
| England Premier League 2 | 2019/09/13 11:00 | Tottenham U23 v Southampton U23 | D | 2-2 |
| England Premier League 2 | 2017/01/30 19:00 | Tottenham U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2016/09/23 18:00 | Southampton U23 v Tottenham U23 | W | 1-0 |
Home History
| England Premier League 2 | 2021/01/29 19:00 | West Ham U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2020/12/12 14:00 | Southampton U23 v Leicester U23 | W | 5-2 |
| England Premier League 2 | 2020/12/04 19:00 | Man Utd U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2020/11/30 19:00 | Southampton U23 v Brighton U23 | L | 0-1 |
| England Premier League 2 | 2020/11/21 13:00 | Liverpool U23 v Southampton U23 | D | 0-0 |
| England Premier League 2 | 2020/11/07 12:00 | Southampton U23 v Man City U23 | W | 5-2 |
| England Premier League 2 | 2020/10/23 12:00 | Derby U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2020/10/18 13:00 | Southampton U23 v Blackburn U23 | L | 0-1 |
Away History
| England Premier League 2 | 2021/01/29 12:00 | Tottenham U23 v Arsenal U23 | D | 1-1 |
| England Premier League 2 | 2021/01/22 16:00 | West Ham U23 v Tottenham U23 | W | 1-2 |
| England Premier League 2 | 2021/01/15 19:00 | Brighton U23 v Tottenham U23 | W | 1-5 |
| England Premier League 2 | 2020/12/19 15:00 | Liverpool U23 v Tottenham U23 | W | 3-4 |
| England Premier League 2 | 2020/12/14 19:00 | Chelsea U23 v Tottenham U23 | L | 3-2 |
| England Premier League 2 | 2020/12/07 19:00 | Blackburn U23 v Tottenham U23 | W | 2-3 |
| England Premier League 2 | 2020/11/30 12:00 | Tottenham U23 v Leicester U23 | L | 1-5 |
| England Premier League 2 | 2020/11/22 17:00 | Man Utd U23 v Tottenham U23 | L | 4-2 |