[9] Brighton U23 3-0 Southampton U23 [12] 2021-04-09 13:00
Stadium: American Express Community Stadium Round: 1
Head to Head
| England Premier League 2 | 2020/11/30 19:00 | Southampton U23 v Brighton U23 | W | 0-1 |
| England Premier League 2 | 2019/11/01 19:00 | Southampton U23 v Brighton U23 | W | 1-4 |
| England Premier League 2 | 2018/03/05 19:00 | Brighton U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2017/10/30 19:00 | Southampton U23 v Brighton U23 | W | 0-1 |
Home History
| England Premier League 2 | 2021/04/04 11:00 | Liverpool U23 v Brighton U23 | L | 3-2 |
| England Premier League 2 | 2021/03/19 14:00 | Blackburn U23 v Brighton U23 | D | 1-1 |
| England Premier League 2 | 2021/03/12 15:00 | Man Utd U23 v Brighton U23 | D | 0-0 |
| England Premier League 2 | 2021/03/07 14:00 | Chelsea U23 v Brighton U23 | D | 0-0 |
| England Premier League 2 | 2021/02/26 14:00 | Brighton U23 v Man City U23 | L | 1-3 |
| England Premier League 2 | 2021/02/22 19:00 | Leicester U23 v Brighton U23 | D | 1-1 |
| England Premier League 2 | 2021/02/05 19:00 | Brighton U23 v West Ham U23 | W | 6-1 |
| England Premier League 2 | 2021/01/22 19:00 | Arsenal U23 v Brighton U23 | L | 5-0 |
Away History
| England Premier League 2 | 2021/03/21 14:00 | Southampton U23 v Liverpool U23 | L | 1-2 |
| England Premier League 2 | 2021/03/15 13:00 | Man City U23 v Southampton U23 | L | 7-1 |
| England Premier League 2 | 2021/03/08 12:00 | Blackburn U23 v Southampton U23 | L | 5-1 |
| England Premier League 2 | 2021/03/05 14:00 | Southampton U23 v Arsenal U23 | D | 2-2 |
| England Premier League 2 | 2021/02/27 14:00 | Southampton U23 v Man Utd U23 | L | 1-2 |
| England Premier League 2 | 2021/02/21 14:00 | Southampton U23 v Derby U23 | W | 1-0 |
| England Premier League 2 | 2021/02/07 14:00 | Southampton U23 v Tottenham U23 | D | 1-1 |
| England Premier League 2 | 2021/01/29 19:00 | West Ham U23 v Southampton U23 | L | 3-1 |