Head to Head
| England Premier League 2 | 2019/02/01 19:00 | Man Utd U23 v Southampton U23 | L | 0-1 |
| England Premier League 2 | 2018/08/24 18:00 | Southampton U23 v Man Utd U23 | D | 1-1 |
| England Premier League 2 | 2017/03/13 19:00 | Man Utd U23 v Southampton U23 | D | 3-3 |
Home History
| England Premier League 2 | 2020/11/27 19:00 | West Ham U23 v Man Utd U23 | L | 2-0 |
| England Premier League 2 | 2020/11/22 17:00 | Man Utd U23 v Tottenham U23 | W | 4-2 |
| England Premier League 2 | 2020/11/06 15:00 | Brighton U23 v Man Utd U23 | W | 2-5 |
| England Premier League 2 | 2020/10/23 18:00 | Man Utd U23 v Everton U23 | W | 2-1 |
| England Premier League 2 | 2020/10/17 13:00 | Arsenal U23 v Man Utd U23 | D | 3-3 |
| England Premier League 2 | 2020/10/02 13:00 | Blackburn U23 v Man Utd U23 | D | 2-2 |
| England Premier League 2 | 2020/09/25 18:00 | Man Utd U23 v Liverpool U23 | L | 3-5 |
| England Premier League 2 | 2020/09/14 18:00 | Man Utd U23 v Leicester U23 | L | 0-2 |
Away History
| England Premier League 2 | 2020/11/30 19:00 | Southampton U23 v Brighton U23 | L | 0-1 |
| England Premier League 2 | 2020/11/21 13:00 | Liverpool U23 v Southampton U23 | D | 0-0 |
| England Premier League 2 | 2020/11/07 12:00 | Southampton U23 v Man City U23 | W | 5-2 |
| England Premier League 2 | 2020/10/23 12:00 | Derby U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2020/10/18 13:00 | Southampton U23 v Blackburn U23 | L | 0-1 |
| England Premier League 2 | 2020/10/03 13:00 | Tottenham U23 v Southampton U23 | L | 2-1 |
| England Premier League 2 | 2020/09/26 15:30 | Southampton U23 v West Ham U23 | D | 2-2 |
| England Premier League 2 | 2020/09/18 18:00 | Southampton U23 v Chelsea U23 | L | 1-4 |