Head to Head
| England Premier League 2 | 2020/12/04 19:00 | Man Utd U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2019/02/01 19:00 | Man Utd U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2018/08/24 18:00 | Southampton U23 v Man Utd U23 | D | 1-1 |
| England Premier League 2 | 2017/03/13 19:00 | Man Utd U23 v Southampton U23 | D | 3-3 |
Home History
| England Premier League 2 | 2021/02/21 14:00 | Southampton U23 v Derby U23 | W | 1-0 |
| England Premier League 2 | 2021/02/07 14:00 | Southampton U23 v Tottenham U23 | D | 1-1 |
| England Premier League 2 | 2021/01/29 19:00 | West Ham U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2020/12/12 14:00 | Southampton U23 v Leicester U23 | W | 5-2 |
| England Premier League 2 | 2020/12/04 19:00 | Man Utd U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2020/11/30 19:00 | Southampton U23 v Brighton U23 | L | 0-1 |
| England Premier League 2 | 2020/11/21 13:00 | Liverpool U23 v Southampton U23 | D | 0-0 |
| England Premier League 2 | 2020/11/07 12:00 | Southampton U23 v Man City U23 | W | 5-2 |
Away History
| England Premier League 2 | 2021/02/22 19:00 | Everton U23 v Man Utd U23 | L | 3-1 |
| England Premier League 2 | 2021/02/12 19:00 | Man Utd U23 v Arsenal U23 | W | 3-0 |
| England Premier League 2 | 2021/02/05 19:00 | Man Utd U23 v Blackburn U23 | W | 6-4 |
| England Premier League 2 | 2021/01/30 13:00 | Liverpool U23 v Man Utd U23 | W | 3-6 |
| England Premier League 2 | 2021/01/18 19:00 | Leicester U23 v Man Utd U23 | L | 4-2 |
| England Premier League 2 | 2020/12/18 12:00 | Chelsea U23 v Man Utd U23 | L | 6-1 |
| England Premier League 2 | 2020/12/13 13:00 | Man Utd U23 v Man City U23 | D | 2-2 |
| England Premier League 2 | 2020/12/04 19:00 | Man Utd U23 v Southampton U23 | W | 3-1 |